104874-02-4Relevant academic research and scientific papers
Enantioselective deprotonative ring contraction of N1-Methyl-N4-Boc-benzo[e][1,4]diazepine-2,5-diones
Antolak, Stephanie A.,Yao, Zhong-Ke,Richoux, Gary M.,Slebodnick, Carla,Carlier, Paul R.
, p. 5204 - 5207 (2014)
N1-Methyl-N4-Boc-benzo[e][1,4]diazepine-2,5-diones were prepared in good yield and high stereochemical purity from five amino acids. Upon deprotonation, these compounds undergo ring contraction to the corresponding quinolone-2,4-diones with high enantioselectivity, providing efficient entry to a potentially useful drug scaffold. Mechanistic commentary and comparisons to related reactions are provided.
Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors
Loudni, Lynda,Roche, Joelle,Potiron, Vincent,Clarhaut, Jonathan,Bachmann, Christian,Gesson, Jean-Pierre,Tranoy-Opalinski, Isabelle
, p. 4819 - 4823 (2008/09/17)
New histone deacetylase inhibitors have been synthesized and evaluated for their activity against non-small lung cancer cell line H661. These compounds have been designed with diversely substituted 1,4-benzodiazepine-2,5-dione moieties as cyclic peptide m
New routes to 1,4-benzodiazepin-2,5-diones
Akssira,Boumzebra,Kasmi,Dahdouh,Roumestant,Viallefont
, p. 9051 - 9060 (2007/10/02)
1,4-benzodiazepin-2,5-diones have been synthesized in good overall yields by two routes, the first one by cyclisation of dipeptides prepared from Boc anthranilic acid and α-amino acid methyl esters, the second one by reaction of N-carboxy α-amino acid anhydrides with Boc anthranilic acid.
