104884-06-2Relevant academic research and scientific papers
Phase Transfer Catalysed Synthesis of Alicyclic Tetraalkyl 1,1-bisphosphonates and Trialkyl 1,1-phosphonocarboxylates.
Hanrahan, Jane R.,Hutchinson, David W.
, p. 3767 - 3768 (1993)
Phase transfer catalysed reaction between 1,ω-dibromoalkanes and tetraalkyl methlyenebisphosphonates or t-butyl diethylphosphonoacetate afforded the alicyclic 1,1-bisphosphonates and 1,1-phosphonocarboxylates respectively.
RECENT WORK ON THE SYNTHESIS OF PHOSPHONATE-CONTAINING, BONE-ACTIVE HETEROCYCLES
Ebetino, Frank H.,Degenhardt, Charles R.,Jamieson, Laura A.,Burdsall, Don C.
, p. 855 - 862 (2007/10/02)
New approaches to the design and synthesis of bone antiresorptive phosphonates have led to the discovery of the cyclic bisphosphonate series and the phosphonoalkylphosphinate heterocyclic series.The latter class, which offers substrates for interesting dianion chemistry, has been shown to include effective bone-active isosteres of the well known bisphosphonates.
