24293-28-5

Upstream product

• 111-29-5 1 ,5-pentanediol 
• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 3976-48-5 1,9-Diphenylnonane 
• 73992-35-5 1,11-Diphenylundecane 
• 33321-42-5 1,1-diphenyl-phosphinanium; toluene-4-sulfonate 
• 104884-06-2 tetraisopropyl 1,1-bisphosphonatecyclohexane 
• 130948-80-0 Cyclohexan-1,1-diyl-1,1-diphosphonsaeure-tetraethylester 
• 31053-03-9 N-(4-methylphenyl)piperidine 
• 57260-91-0 Cyclohexanon-dimethyl-dithioacetal-S-oxid 
• 1670-47-9 1,1-diethoxycyclohexane 
• 108-94-1 cyclohexanone 
• 956-82-1 3-methylcyclopentadecanone 
• 146273-48-5 Toluene-4-sulfonic acid (4E,8E)-8-methyl-10-oxo-cyclopentadeca-4,8-dienyl ester 
• 104883-95-6 Cyclohexan-1,1-diyl-1,1-diphosphonsaeure 
• 58582-08-4 5-tert.-butoxy-pentyl tosylate 

Relevant academic research and scientific papers

Novel 18F-Labeled Radioligands for Positron Emission Tomography Imaging of Myelination in the Central Nervous System

Myelin is the protective sheath that surrounds nerves in vertebrates to protect axons, which thereby facilitates impulse conduction. Damage to myelin is associated with many neurodegenerative diseases such as multiple sclerosis and also includes spinal co

Conformational locking for band gap control in 3,4-propylenedioxythiophene based electrochromic polymers

We report a tethered poly(3,4-propylenedioxythiophene) derivative with a built-in polymer conformation restriction which locks the conjugated chain at a specific dihedral angle, thus providing a handle in which to tune the optical and electronic properties of the material. The Royal Society of Chemistry 2006.

Tethered PProDOTs: Conformationally restricted 3,4-propylenedioxythiophene based electroactive polymers

Herein we report a complete family of conformationally restricted PProDOT derivatives with varying alkylene tether lengths. It was found that variation of the tether length and structure of the electropolymerizable monomer was successful in the fine-tuning of the electrochemical and optical properties of the subsequent material. It was found that the band gap of the materials could be varied between 1.94 and 2.26 eV, with the "sweet spot" for obtaining the maximum electronic band gap existing at the n = 6 tether length, while maintaining low redox potentials. It was also found that these polymers exhibited stable electrochromic behavior with colors varying from blue-purple to orange in their neutral states and transmissive in their doped states. The Royal Society of Chemistry 2007.

Aggregation-induced emission based on a fluorinated macrocycle: visualizing spontaneous and ultrafast solid-state molecular motions at room temperature: via F?F interactions

We for the first time report the efficient construction of novel tetraphenethylene (TPE)-based macrocycles with various mechanofluorochromism (MFC) behaviors involving solid-state molecular motions. We were able to facilely regulate the diverse solid-stat

Tetrastyrene macrocyclic compound with force-induced fluorescence color-changing performance and synthesis method and application thereof

The invention discloses a tetrastyrene macrocyclic compound with force-induced fluorescence color changing performance. The compound is connected with an alkyl chain structural unit through the strongfluorescence property of the tetrastyrene macrocyclic c

A PET contrast compound for early diagnosis of cardiovascular diseases and use thereof

The present invention provides: a precursor compound for the production of a radioactive compound for efficient imaging of heart; a radioactive compound produced using the precursor compound; and uses thereof as a contrast medium for PET imaging. According to the present invention, it is an object of the present invention to provide an improved novel PET imaging compound having a low water absorption rate and an improved removal rate in the liver.COPYRIGHT KIPO 2019

DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF

Derivatives of dolastatin 10 and uses thereof, the structures of which are shown as formula I, II, III and IV are provided.

Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands

A series of 2-methoxyphenyl piperazine analogues containing a triazole ring were synthesized and their in vitro binding affinities at human dopamine D2 and D3 receptors were evaluated. Compounds 5b, 5c, 5d, and 4g, demonstrate high a

Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET

Multidrug resistance-associated protein 1 (MRP1) is a drug efflux transporter that has been implicated in the pathology of several neurological diseases and is associated with development of multidrug resistance. To enable measurement of MRP1 function in

Development of a new thiol site-specific prosthetic group and its conjugation with [Cys40]-exendin-4 for in vivo targeting of insulinomas

A new tracer, N-5-[18F]fluoropentylmaleimide ([ 18F]FPenM), for site-specific labeling of free thiol group in proteins and peptides was developed. The tracer was synthesized in three steps (18F displacement of the aliphatic tosylate, di-Boc removal by TFA to expose free amine, and incorporation of the free amine into a maleimide). The radiosynthesis was completed in 110 min with 11-17% radiochemical yield (uncorrected), and specific activity of 20-49 GBq/μmol. [18F]FPenM showed comparable labeling efficiency with N-[2-(4-[18F] fluorobenzamido)ethyl]maleimide ([18F]FBEM). Its application was demonstrated by conjugation with glucagon-like peptide type 1 (GLP-1) analogue [cys40]-exendin-4. The cell uptake, binding affinity, imaging properties, biodistribution, and metabolic stability of the radiolabeled [ 18F]FPenM-[cys40]-exendin-4 were studied using INS-1 tumor cells and INS-1 xenograft model. Positron emission tomography (PET) results showed that the new thiol-specific tracer, [18F]FPenM-[cys 40]-exendin-4, had high tumor uptake (20.32 ± 4.36%ID/g at 60 min postinjection) and rapid liver and kidney clearance, which was comparable to the imaging results with [18F]FBEM-[cys40]-exendin-4 reported by our group.