10489-16-4Relevant articles and documents
Enantioselective Synthesis of Axially Chiral Biaryls via Cu-Catalyzed Acyloxylation of Cyclic Diaryliodonium Salts
Zhu, Kai,Xu, Kai,Fang, Qi,Wang, Yi,Tang, Bencan,Zhang, Fengzhi
, p. 4951 - 4957 (2019)
We report here a Cu-catalyzed enantioselective acyloxylation of cyclic diaryliodonium salts. With readily available cyclic diaryliodonium salts and ubiquitous aliphatic or (hetero)aromatic carboxylic acids as the starting materials, various axially chiral
Highly efficient chromatographic resolution of α,α′- dihydroxybiaryls
Huang, Junmin,Li, Tingyu
, p. 5821 - 5823 (2005)
(Graph Presented) Separation factors as high as 115 were observed for the chromatographic resolution of many α,α′-dihydroxybiaryls with a single chiral stationary phase made from readily available amino acid derivatives. The stationary phase works well for biphenyl-type compounds. It works extremely well for larger bis-aromatic compounds, such as binaphthyl-type compounds.
Hexafluoroisopropanol-Enabled Copper-Catalyzed Asymmetric Halogenation of Cyclic Diaryliodoniums for the Synthesis of Axially Chiral 2,2′-Dihalobiaryls
Ke, Jie,Zu, Bing,Guo, Yonghong,Li, Yingzi,He, Chuan
, p. 329 - 333 (2021/01/13)
An efficient asymmetric halogenation of cyclic diaryliodonium salts is demonstrated, which gives access to a wide range of axially chiral 2,2′-dihalobiaryls in good to excellent yields and with excellent enantioselectivities. The use of CuX with chiral bisoxazoline ligand and tetrabutylammonium halides in the unique solvent of hexafluoroisopropanol (HFIP) led to the best results in the process. The axially chiral 2,2′-dihalobiaryls can be transformed into a number of enantiopure chiral ligands that could be potentially useful in asymmetric catalysis.
Chiral phosphoric acid catalyzed enantioselective synthesis of β-amino-α,α-difluoro carbonyl compounds
Kashikura, Wataru,Mori, Keiji,Akiyama, Takahiko
supporting information; experimental part, p. 1860 - 1863 (2011/06/20)
A biphenol-based chiral phosphoric acid bearing a 9-anthryl group at each of the 3,3′-positions catalyzed the asymmetric Mannich-type reaction of N-Boc imine with difluoroenol silyl ethers in the presence of MS3A in THF to afford β-amino-α,α-difluoroketon
