1048930-76-2

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 1394173-90-0 C₁₄H₁₄BrNO₆ 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 40155-54-2 ethyl 4-(4-bromophenyl)-2,4-dioxobutanoate 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 1357157-80-2 ethyl 3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazole-5-carboxylate 
• 1357157-92-6 (3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methanol 
• 1357158-03-2 tert-butyl 2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate 
• 1357158-08-7 2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethanol 
• 1357158-13-4 2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)ethyl methanesulfonate 
• 1357157-59-5 2-(4-fluorobenzylthio)-1-(2-((3-(4-bromophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)-ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 
• 1357157-73-3 ethyl 1-(2-bromoethyl)-3-(4-bromophenyl)-1H-pyrazole-5-carboxylate 
• 1446419-23-3 C₁₃H₁₄BrN₃O₂ 

Relevant academic research and scientific papers

Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety

A series of novel oxazolidinone derivatives with nitrogen-containing fused heterocyclic moiety were designed and synthesized in this article. Their antibacterial activities were measured against S. aureus, MRSA and MSSA by MIC assay. Most of them exhibite

Hydroxamic Acid-Based Histone Deacetylase (HDAC) inhibitors bearing a pyrazole scaffold and a cinnamoyl linker

Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, recent studies have demonstrated that epigenetic mechanisms are also implicated in the insurgence and development of cancer. Patterns of the epigenetic component in

1. 3, 5 - tri-substituted pyrazole compound and its preparation method and application

The invention discloses 1,3,5-trisubstituted pyrazole compounds, and a preparation method and application thereof. The structure of the compounds is shown as a general formula (I), and in the general formula (I), R1 is hydrogen, halogens, methyl or triflu

Cascade regioselective synthesis of pyrazoles from nitroallylic acetates and N-tosyl hydrazine

A simple, practical, and regioselective synthetic protocol for the formation of pyrazoles was developed. Unlike all other previously reported reactions of nitroallylic acetates, this process was initiated by a S N2 reaction at the electrophilic γ site. A plausible mechanism for the cascade SN2-Michael synthesis is proposed.

Synthesis and acrosin inhibitory activities of 5-phenyl-1H-pyrazole-3- carboxylic acid amide derivatives

A series of novel 5-phenyl-1H-pyrazole-3-carboxylic acid amide derivatives were designed, synthesized, and their acrosin inhibitory activities in vitro were evaluated. The results of the acrosin inhibitory activity showed that all target compounds were mo

Design and synthesis of novel pyrazole-based Lp-PLA2 inhibitors

A series of novel pyrazole-based lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors have been designed and synthetized by a variety of acetophenones via a 10-step convergent approach. The synthetic approach is carefully opt

1,3-Dipolar cycloaddition of diazoacetate compounds to terminal alkynes promoted by Zn(OTf)2: an efficient way to the preparation of pyrazoles

A series of pyrazoles were prepared in good yields via 1,3-dipolar cycloaddition of diazoacetate compounds to terminal alkynes promoted by Zn(OTf)2 under mild conditions. It was supposed that the reaction was through the intermediate of Zn alky