1048958-13-9

Upstream product

• 3340-78-1 2-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 149104-90-5 4-acetylphenylboronic acid 
• 591-50-4 iodobenzene 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst

This report describes a highly enantioselective oxidative sp3 C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C-H asymmetric arylation of THIQs.

Copper-catalyzed oxidative sp3 C-H bond arylation with aryl boronic acids

(Chemical Equation Presented) An efficient method was developed for arylation of sp3 C-H bonds using copper bromide as catalyst in absence of directing group with arylboronic acids. The oxidative arylation provides easy access to biologically a