3340-78-1

Basic information

• Product Name: 2-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 3340-78-1
• Molecular Formula: C₁₅H₁₅N
• Molecular Weight: 209.2863
• Mol File: 3340-78-1.mol
• Article Data: 113

Chemical Properties

• Melting Point: 45-46 °C
• Boiling Point: 198 °C(Press: 16 Torr)
• Appearance: /
• Density: 1.092±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.94±0.40(Predicted)
• CAS DataBase Reference: 2-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1,2,3,4-tetrahydroisoquinoline(3340-78-1)
• EPA Substance Registry System: 2-phenyl-1,2,3,4-tetrahydroisoquinoline(3340-78-1)

Safety Data

• Hazardous Substances Data: 3340-78-1(Hazardous Substances Data)

Usage

Uses

2-Phenyl-1,2,3,4-tetrahydroisoquinoline is a reactant that is used in acetic acid promoted metal-free aerobic carbon-carbon bond forming reactions at α-position of tertiary amines.

Upstream product

• 62-53-3 aniline 
• 493-05-0 isochromane 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 325723-04-4 Phenylbiphenyl-2,2'-ylenebismuth diacetate 
• 108-86-1 bromobenzene 
• 153333-52-9 1-(2-iodoethyl)-2-(iodomethyl)benzene 
• 119-65-3 isoquinoline 
• 32347-03-8 N-(2-bromobenzylidene)aniline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 50844-92-3 N-(2-bromobenzyl)benzenamine 
• 1699-52-1 2-formyl-1,2,3,4-tetrahydroisoquinoline 
• 108-90-7 chlorobenzene 
• 103-69-5 N-ethyl-N-phenylamine 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 55662-89-0 2-phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile 
• 850130-95-9 1,2,3,4-tetrahydro-1-(nitromethyl)-2-phenylisoquinoline 
• 1150587-82-8 2,2-difluoro-1-phenyl-2-( 2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone 
• 1150588-11-6 2,2-difluoro-2-(2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-(trimethylsilyl)ethanone 
• 1150588-13-8 1-(tert-butyldimethylsilyl)-2,2-difluoro-2-(2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone 
• 6772-51-6 2-phenyl-3,4-dihydroisoquinolin-1(2H)-one 
• 1042719-26-5 1,2,3,4-tetrahydro-1-(1-nitropropyl)-2-phenylisoquinoline 
• 1250257-17-0 2-phenyl-1-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline 
• 1250257-33-0 2-phenyl-1-(trifluoromethyl)-1,2-dihydroisoquinoline 
• 1338367-23-9 1-(5-bromo-1H-indol-3-yl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 1350895-85-0 2-phenyl-1-(4-phenylbut-1-yn-1-yl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

The Photocatalyzed Aza-Henry Reaction of N-Aryltetrahydroisoquinolines: Comprehensive Mechanism, H?- versus H+-Abstraction, and Background Reactions

The cross-dehydrogenative coupling (CDC) reaction of N-aryltetrahydroisoquinolines (THIQ) is one of the most exploited photocatalytic transformation and a test reaction for an exceptional variety of catalysts. However, its mechanism remained unclear conce

Direct Near Infrared Light–Activatable Phthalocyanine Catalysts

The high penetration of near-infrared (NIR) light makes it effective for use in selective reactions under light-shielded conditions, such as in sealed reactors and deep tissues. Herein, we report the development of phthalocyanine catalysts directly activa

Direct Arylation of Distal and Proximal C(sp3)-H Bonds of t-Amines with Aryl Diazonium Tetrafluoroborates via Photoredox Catalysis

A visible light-mediated arylation protocol for t-amines has been reported through the coupling of γ- and α-amino alkyl radicals with different aryl diazonium salts using Ru(bpy)3Cl2·6H2O as a photocatalyst. Structurally different 9-aryl-9,10-dihydroacridine, 1-aryl tetrahydroisoquinoline, hexahydropyrrolo[2,1-a]isoquinoline, and hexahydro-2H-pyrido[2,1-a]isoquinoline frameworks with different substitution patterns have been synthesized in good yield using this methodology.

Electrocatalytic C(sp3)-H/C(sp)-H cross-coupling in continuous flow through TEMPO/copper relay catalysis

Electrocatalytic dehydrogenative C(sp3)-H/C(sp)-H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis. The reaction