1048998-70-4

Basic information

• Product Name: ethyl 1-(2-acetoxyethyl)-6-(3-chloro-4-fluorophenoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate
• Synonyms: ethyl 1-(2-acetoxyethyl)-6-(3-chloro-4-fluorophenoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS NO: 1048998-70-4
• Molecular Weight: 447.847
• Mol File: 1048998-70-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 1-(2-acetoxyethyl)-6-(3-chloro-4-fluorophenoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(2-acetoxyethyl)-6-(3-chloro-4-fluorophenoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate(1048998-70-4)
• EPA Substance Registry System: ethyl 1-(2-acetoxyethyl)-6-(3-chloro-4-fluorophenoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate(1048998-70-4)

Safety Data

• Hazardous Substances Data: 1048998-70-4(Hazardous Substances Data)

Upstream product

• 627-10-1 2-iodoethyl acetate 
• 1048998-65-7 ethyl 6-(3-chloro-4-fluorophenoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate 

Downstream Products

• 1048998-35-1 6-(3-chloro-4-fluorophenoxy)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be able to inhibit the strand transfer step of the virus integration process in the micromolar range. Docking studies and quantum mechanics calculations were used to rationalize these data.