627-10-1

Basic information

• Product Name: 2-iodo-1-ethanol acetate
• Synonyms: 2-iodo-1-ethanol acetate
• CAS NO: 627-10-1
• Molecular Formula: C₄H₇IO₂
• Molecular Weight: 214.00165
• Mol File: 627-10-1.mol

Chemical Properties

• Boiling Point: 95-96 °C(Press: 43 Torr)
• Appearance: /
• Density: 1.831±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-iodo-1-ethanol acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-1-ethanol acetate(627-10-1)
• EPA Substance Registry System: 2-iodo-1-ethanol acetate(627-10-1)

Safety Data

• Hazardous Substances Data: 627-10-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Iodo-1-ethanol acetate is used as a reagent in organic synthesis for its ability to facilitate the formation of esters. Its reactivity allows for the creation of a wide range of organic compounds, making it a valuable component in chemical reactions.
Used in Pharmaceutical Synthesis:
2-Iodo-1-ethanol acetate is used as a precursor in the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs and medicinal compounds, enhancing the range of treatments available for various health conditions.
Used in Agrochemical Synthesis:
2-Iodo-1-ethanol acetate is also utilized in the synthesis of agrochemicals, serving as a precursor for the development of new pesticides, herbicides, and other agricultural chemicals. Its role in these processes helps to improve crop protection and yield.
Used in the Synthesis of Bioactive Compounds:
Due to its potential use in the synthesis of various bioactive compounds, 2-Iodo-1-ethanol acetate is employed in the development of substances that can interact with biological systems. This application opens up possibilities for new discoveries in medicine, agriculture, and other fields where bioactive compounds play a crucial role.

Upstream product

• 497-26-7 2-methyl-1,3-dioxolane 
• 74-85-1 ethene 
• 64-19-7 acetic acid 
• 764-78-3 ethylene glycol divinyl ether 
• 507-02-8 acetyl iodide 
• 107-21-1 ethylene glycol 

Downstream Products

• 2260-50-6 acetylcholine iodide 
• 69733-59-1 C₁₀H₈Cl₄N₂O₄ 
• 86399-15-7 2-(2-Bromo-ethyl)-5,5-dimethyl-cyclohexanone 
• 87867-17-2 N(α)-benzoyl-N(τ)-(2-acetoxyethyl)histidine methyl ester 
• 131242-37-0 N-(β-acetoxyethyl)cocain iodide 
• 199385-60-9 1-(2-methylphenyl)-4-[(4,7,7-trimethyl-3-oxo-2-carboxymethyl-bicyclo[2.2.1]hept-2-yl)carbonyl]-piperazine 
• 1048998-70-4 ethyl 1-(2-acetoxyethyl)-6-(3-chloro-4-fluorophenoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1048998-71-5 ethyl 1-(2-acetoxyethyl)-4-oxo-6-(phenylthio)-1,4-dihydroquinoline-3-carboxylate 
• 1048998-72-6 ethyl 1-(2-acetoxyethyl)-6-(2,4-dichlorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1048998-77-1 ethyl 1-(2-acetoxyethyl)-6-(2,4-dichlorobenzoyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 56703-55-0 but-3-yn-1-yl acetate 

Relevant articles and documents

Carbodeoxygenation of biomass: The carbonylation of glycerol and higher polyols to monocarboxylic acids

Glycerol is converted to a mixture of butyric and isobutyric acid by rhodium- or iridium-catalysed carbonylation using HI as the co-catalyst. The initial reaction of glycerol with HI results in several intermediates that lead to isopropyl iodide, which upon carbonylation forms butyric and isobutyric acid. At low HI concentration, the intermediate allyl iodide undergoes carbonylation to give vinyl acetic acid and crotonic acid. Higher polyols CnH n+2(OH)n are carbonylated to the corresponding C n+1 mono-carboxylic acids. Copyright

Acyl iodides in organic synthesis: VI. Reactions with vinyl ethers

Reactions of acetyl iodide with butyl vinyl ether, 1,2-divinyloxyethane, phenyl vinyl ether, 1,4-di-vinyloxybenzene, and divinyl ether were studied. Vinyl ethers derived from aliphatic alcohols (butyl vinyl ether and 1,2-divinyloxyethane) react with acetyl iodide in a way similar to ethyl vinyl ether, i.e., with cleavage of both O-Csp2 and Alk-O ether bonds. From butyl vinyl ether, a mixture of vinyl iodide, butyl acetate, vinyl acetate, and butyl iodide is formed, while 1,2-divinyloxyethane gives rise to vinyl iodide, vinyl acetate, and 2-iodoethyl acetate. The reaction of acetyl iodide with divinyl ether involves cleavage of only one O-Csp2 bond, yielding vinyl acetate and vinyl iodide. In the reactions of acetyl iodide with phenyl vinyl ether and 1,4-divinyloxybenzene, only the O-CVin bond is cleaved, whereas the O-CAr bond remains intact.

Synthesis of Ethylene Glycol Acetates Catalyzed by Potassium Iodide and Metal Acetate

The catalytic activities of various kinds of binary systems consisting of KI and metal acetate were tested in liquid phase oxidation of ethylene in acetic acid at various pressures.KI-Mn(OCOCH3)2 was found to be the most reactive system and new material, CH3COOCH2CH2OCOCH2OCOCH3, was formed as a major by-product.It was also found that the main product at an early stage of the reaction was ethylene glycol monoacetate, from which other products were formed consecutively.It is considered that catalytic reaction does not proceed via ICH2CH2I, but via ICH2CH2OH which is formed by the oxidation of ethylene with HIO.On the basis of the rate equation and the results under various reaction conditions, a mechanism of the KI-Mn(OCOCH3)2-catalyzed reaction has been proposed.