1049103-16-3

Basic information

• Product Name: 5-Methanesulfonyl-3-[3-(2-piperidin-1-yl-ethylsulfanyl)-4-trifluoromethyl-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
• CAS NO: 1049103-16-3
• Molecular Weight: 488.598
• Mol File: 1049103-16-3.mol

Chemical Properties

• CAS DataBase Reference: 5-Methanesulfonyl-3-[3-(2-piperidin-1-yl-ethylsulfanyl)-4-trifluoromethyl-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methanesulfonyl-3-[3-(2-piperidin-1-yl-ethylsulfanyl)-4-trifluoromethyl-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine(1049103-16-3)
• EPA Substance Registry System: 5-Methanesulfonyl-3-[3-(2-piperidin-1-yl-ethylsulfanyl)-4-trifluoromethyl-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine(1049103-16-3)

Safety Data

• Hazardous Substances Data: 1049103-16-3(Hazardous Substances Data)

Upstream product

• 4706-22-3 N-(2-Mercaptoethyl)piperidine 
• 1049102-98-8 5-methanesulfonyl-3-(3-nitro-4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 

Relevant articles and documents

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions

A novel class of tetrahydropyrido-pyrazole thioether amines that display potency against human Cathepsin S have been previously reported. Here, further SAR investigations of the P3, P4, and P5 regions are described. In particular, 4-fluoropiperidine is identified as a competent P3 binding element when utilized in conjunction with a (S)-2-hydroxypropyl linker-containing P5 moiety and oxamide or sulfonamide P4 substitution.