4706-22-3

Basic information

• Product Name: 2-(piperidin-1-yl)ethanethiol
• Synonyms: 1-Piperidineethanethiol; 1-Piperidineethanethiol (9CI); 2-(Piperidin-1-yl)ethanethiol
• CAS NO: 4706-22-3
• Molecular Formula: C₇H₁₅NS
• Molecular Weight: 145.2657
• Mol File: 4706-22-3.mol

Chemical Properties

• Boiling Point: 207.4°C at 760 mmHg
• Flash Point: 79.2°C
• Density: 0.974g/cm³
• Vapor Pressure: 0.225mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2-(piperidin-1-yl)ethanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(piperidin-1-yl)ethanethiol(4706-22-3)
• EPA Substance Registry System: 2-(piperidin-1-yl)ethanethiol(4706-22-3)

Safety Data

• Hazardous Substances Data: 4706-22-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(piperidin-1-yl)ethanethiol is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of diverse molecular entities with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(piperidin-1-yl)ethanethiol is utilized as a key component in the production of agrochemicals, such as pesticides and herbicides. Its role in these applications aids in enhancing crop protection and yield.
Used in Fine Chemicals Production:
2-(piperidin-1-yl)ethanethiol is employed as a building block in the synthesis of fine chemicals, which are high-purity chemicals used in various industries, including cosmetics, fragrances, and flavorings.
Used as a Protective Agent in Biochemistry:
2-(piperidin-1-yl)ethanethiol serves as a protective agent for sulfhydryl groups in proteins and peptides, playing a crucial role in maintaining the structural integrity and functionality of these biomolecules.
Used in Polymer Science:
2-(piperidin-1-yl)ethanethiol is used as a precursor in the synthesis of cross-linking agents for polymers, which are essential for improving the mechanical properties and stability of polymeric materials.
Used in Surfactant Manufacturing:
In the surfactant industry, 2-(piperidin-1-yl)ethanethiol is utilized in the production of surfactants, which are compounds that reduce the surface tension of liquids, finding applications in detergents, wetting agents, and emulsifiers.
Used in Dye Industry:
2-(piperidin-1-yl)ethanethiol is employed in the manufacture of dyes, contributing to the development of colorants used in various applications, such as textiles, plastics, and inks.
Used in Rubber Chemicals Production:
2-(piperidin-1-yl)ethanethiol is used in the production of rubber chemicals, which are additives that enhance the performance and properties of rubber materials in various industrial applications.
It is important to handle 2-(piperidin-1-yl)ethanethiol with caution, as it is toxic if ingested or inhaled and can cause skin and eye irritation upon contact. Proper safety measures should be taken during its use to minimize potential health risks.

Upstream product

• 420-12-2 thirane 
• 110-89-4 piperidine 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 17356-08-0 thiourea 

Downstream Products

• 101114-05-0 thiobenzoic acid S-(2-piperidino-ethyl ester); hydrochloride 
• 7327-11-9 1-(2-benzhydrylmercapto-ethyl)-piperidine 
• 1049103-16-3 5-Methanesulfonyl-3-[3-(2-piperidin-1-yl-ethylsulfanyl)-4-trifluoromethyl-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 
• 858827-74-4 4-nitro-benzoic acid-[2-(2-piperidino-ethylmercapto)-ethylamide] 
• 57616-53-2 7-chloro-5-(2-chloro-phenyl)-2-(2-piperidin-1-yl-ethylsulfanyl)-3H-benzo[e][1,4]diazepine 
• 88873-87-4 1-phenyl-2-(piperidinoethylthiomethyl)-propan-1-one 
• 89816-43-3 2,2-bis-(piperidinoethylthiomethyl)-1-phenylethan-1-one 
• 100004-41-9 2-(2-Piperidin-1-yl-ethylsulfanylmethyl)-cyclohexanone 
• 206434-69-7 6-methoxy-2-(4-methoxyphenyl)-3-[4-(2-(piperidin-1-yl)ethylthio)benzoyl]benzo[b]thiophene 

Relevant articles and documents

LIPOCATIONIC POLYMERS AND USES THEREOF

Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

The ability to control chemical functionality is an exciting feature of modern polymer science that enables precise design of drug delivery systems. Ring-opening polymerization of functional monomers has emerged as a versatile method to prepare clinically translatable degradable polyesters.1 A variety of functional groups have been introduced into lactones; however, the direct polymerization of tertiary amine functionalized cyclic esters has remained elusive. We report a strategy that enabled the rapid synthesis of >130 lipocationic polyesters directly from functional monomers without protecting groups. These polymers are highly effective for siRNA delivery at low doses in vitro and in vivo.

NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF

The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions

A novel class of tetrahydropyrido-pyrazole thioether amines that display potency against human Cathepsin S have been previously reported. Here, further SAR investigations of the P3, P4, and P5 regions are described. In particular, 4-fluoropiperidine is identified as a competent P3 binding element when utilized in conjunction with a (S)-2-hydroxypropyl linker-containing P5 moiety and oxamide or sulfonamide P4 substitution.

Substituted benzo(b)thiophene compounds having activity as selective estrogen receptor modulators

The present invention provides compounds with nitrogen, sulfur or carbon linked basic side chains of formula where R1and R2are independently hydrogen, halo, hydroxy, alkoxy, alkylcarbonyloxy, alkoxycarbonyl, alkoxycarbonyloxy, arylca

Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs

Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti--inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.

Structure-Activity Relationships among Di- and Tetramine Disulfides Related to Benextramine

The synthesis and irreversible α-blocking activity in the rat vas deferens of a series of tetra- and diamine disulfides 2-38, structural analogues of benextramine (BHC), are described. All compounds containing a central cystamine moiety displayed an irreversible α-adrenergic blockade at concentrations ranging from 10-4 to 6*10-6 M. Potency was increased in cystamines N,N'-disubstituted with 6-aminohexyl groups, especially when the outer nitrogen atoms bear arylalkyl substituents or are enclosed in a ring. However, N,N,N',N'-tetrasubstituted cystamines were poor blockers. Structural specificity in the outer portion of the tetramine disulfide is low, since many types of substituents gave rise to potent α-blockers. Even replacement of the outer amines with nonbasic ethers or amides was observed to maintain irreversible α-blockade.