1049138-68-2Relevant academic research and scientific papers
Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent Gram-positive antibacterial activity
Jarvest, Richard L.,Berge, John M.,Brown, Murray J.,Brown, Pamela,Elder, John S.,Forrest, Andrew K.,Houge-Frydrych,O'Hanlon, Peter J.,McNair, David J.,Rittenhouse, Stephen,Sheppard, Robert J.
, p. 665 - 668 (2007/10/03)
Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.
