104917-95-5

Upstream product

• 13028-46-1 9-methyl-1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-one 
• 104918-03-8 2-(1-Acetyl-3-methyl-1H-indol-2-ylmethyl)-malonic acid dimethyl ester 
• 104918-04-9 2-(3-Methyl-1H-indol-2-ylmethyl)-malonic acid dimethyl ester 
• 104918-05-0 9a-Methoxy-9-methylene-1,2,9,9a-tetrahydro-pyrrolo[1,2-a]indol-3-one 
• 72448-32-9 N-acetyl-2-bromomethyl-3-methylindole 
• 90163-02-3 2,3-Dihydro-3-oxo-1H-pyrrolo<1,2-a>indol-9-carbaldehyd 

Relevant academic research and scientific papers

SELECTIVE SIDE-CHAIN BROMINATION OF N-ACYL-2,3-DIALKYLINDOLES: SYNTHESIS AND CHEMICAL MODIFICATION OF PYRROLOINDOLES

Selective side-chain modification of N-acyl-2,3-dialkylindoles at C-2, effected by bromination with NBS, and at C-3, effected via SN' type reactions of 2,3-dialkyl-2-methoxy-3-methylene indolines generated by low temperature bromination-methanolysis of N-acylindoles, can be usefully applied to the synthesis of substituted pyrrolo indoles of potential value in the synthesis of mitosene analogs.

MITOMYCIN ANTIBIOTICS: SYNTHESIS OF 9a-FUNCTIONALIZED MITOSANES

Two closely related rapid entries into the mitosane ring system are described which allow for structural modifications.First examples of a hydroxylation and a methoxylation at the 9a-position of mitosanes are reported.