104920-79-8

Usage

Uses

Used in Pharmaceutical Research:
Benzeneacetic acid, 4-fluoro-α-formyl-, ethyl ester is utilized as a building block in the synthesis of various pharmaceutical drugs and organic compounds. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Organic Chemistry:
Benzeneacetic acid, 4-fluoro-.alpha.-forMyl-, ethyl ester is also commonly used as a reagent in chemical reactions and organic synthesis processes. Its versatility and reactivity contribute to the advancement of organic chemistry research and the creation of novel organic compounds.
Used in Analgesic and Anti-inflammatory Medications:
Benzeneacetic acid, 4-fluoro-α-formyl-, ethyl ester is known for its potential therapeutic applications, particularly in the development of analgesic and anti-inflammatory medications. Its chemical properties may contribute to the effectiveness of these medications in managing pain and inflammation.
Used in Chemical Reactions and Organic Synthesis Processes:
Due to its unique chemical properties, Benzeneacetic acid, 4-fluoro-α-formyl-, ethyl ester is employed in various chemical reactions and organic synthesis processes. It serves as a key component in the production of a wide range of organic compounds, further expanding its applications across different industries.

Upstream product

• 109-94-4 formic acid ethyl ester 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 

Downstream Products

• 104920-88-9 8-amino-4-(4-fluorophenyl)tetrazolo<1,5-a><1,8>naphthyridine 
• 104920-91-4 8-hydroxy-4-(4-fluorophenyl)tetrazolo<1,5-a><1,8>naphthyridine 
• 104949-89-5 7-acetamido-2-chloro-3-(4-fluorophenyl)-1,8-naphthyridine 
• 104949-87-3 7-acetamido-3-(4-fluorophenyl)-2-hydroxy-1,8-naphthyridine 
• 104920-85-6 8-acetamido-4-(4-fluorophenyl)tetrazolo<1,5-a><1,8>naphthyridine 
• 104920-80-1 7-amino-3-(4-fluorophenyl)-2-hydroxy-1,8-naphthyridine 

Relevant academic research and scientific papers

Study on the synthesis and biological activities of α-substituted arylacetates derivatives

Anisodamine was isolated from the medicinal herb, it was used in the treatment of gastrointestinal smooth muscle spasm, infective toxic shock and organophosphorus intoxication. But there is no report about anisodamine with α-glucosidase inhibitory activity. In order to find novel α-glucosidase inhibitors, a series of α-substituted arylacetates derivatives have been synthesized based on the active unit of anisodamine. In α-glucosidase assay, compound 9 in Schiff base form and compound 22 in ester form show strong inhibition against α-glucosidase with IC50value of 46.81?μM and 83.76?μM, respectively. Compounds 9 and 22 exhibit comparable good antidiabetic activities as commercial drug Glimepiride. In addition, Schiff bases of α-substituted arylacetates show antitumor activities against human cancer cell lines, where compound 9 with thiourea moiety performs the best antitumor activity. We anticipate that our research will provide potential candidate scaffolds for antidiabetic drug design.

Synthesis and anticancer evaluation of 3-substituted quinolin-4-ones and 2,3-dihydroquinolin-4-ones

A series of 3-aryl-5,7-dimethoxyquinolin-4-ones 8 and 3-aryl-5,7-dimethoxy- 2,3-dihydroquinolin-4-ones 13 were synthesized in good yields. Demethylation under a range of conditions afforded the corresponding 5-hydroxy and 5,7-dihydroxy derivatives. Biolog

Lewis base catalyzed asymmetric hydrosilylation of α-substituted β-enamino esters: Facile access to enantioenriched β2-amino esters via dynamic kinetic resolution

A chiral Lewis base organocatalyzed asymmetric hydrosilylation of α-substituted β-enamino esters is presented. The reactions proceeded through dynamic kinetic resolution to afford various enantioenriched β2-amino esters with high yields (up to

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design concept involved replacement of the requisite sp3-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, pyrroles, and isoxazolinones is described.