10493-27-3

Upstream product

• 2024-83-1 veratronitrile 
• 2169-98-4 3,4-Dimethoxy-benzaldehyde oxime 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 104186-19-8 4-[5-(3,4-Dimethoxy-phenyl)-tetrazol-2-ylmethyl]-2,6-dimethyl-phenol 
• 91759-56-7 4-(2H-Tetrazol-5-yl)-benzene-1,2-diol 
• 91759-58-9 Ethyl 5-(3,4-dimethoxyphenyl)tetrazol-2-yl acetate 
• 91759-64-7 [5-(3,4-Dihydroxy-phenyl)-tetrazol-2-yl]-acetic acid 
• 91759-61-4 [5-(3,4-Dimethoxy-phenyl)-tetrazol-2-yl]-acetic acid 
• 125775-79-3 2-[3-(4,6-bis-trichloromethyl-s-triazin-2-yl)phenyl]-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole 
• 125775-93-1 2-[4-(4,6-bis-trichloromethyl-s-triazin-2-yl)phenylethenyl]-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole 
• 173309-46-1 3-[5-(3,4-Dimethoxy-phenyl)-tetrazol-2-yl]-1-(4-methoxy-phenyl)-propan-1-one 
• 92595-41-0 3-[5-(3,4-Dimethoxy-phenyl)-tetrazol-2-ylmethyl]-4-hydroxy-5-methoxy-benzaldehyde 
• 104065-30-7 3-[5-(3,4-Dimethoxy-phenyl)-tetrazol-1-ylmethyl]-4-hydroxy-5-methoxy-benzaldehyde 
• 94772-01-7 C₁₈H₁₇ClN₈O₅S 
• 94772-00-6 C₁₈H₁₈N₈O₅S 
• 94772-07-3 [5-(3,4-Dimethoxy-phenyl)-tetrazol-2-yl]-acetic acid [1-(2,4,6-trimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide 

Relevant academic research and scientific papers

SYNTHESIS OF SOME 5-ARYL(HETARYL)TETRAZOLES BY ULTRASONICATION

The influence of ultrasound of the 1,3-dipolar cycloaddition of azides to organic nitriles to form of 1H-5-aryl(hetaryl)tetrazoles was studied.It was shown that ultrasound decreases the reaction time, and increases the yield of the desired compounds.

RETRACTED ARTICLE: Antiamoebic activity of synthetic tetrazoles against Acanthamoeba castellanii belonging to T4 genotype and effects of conjugation with silver nanoparticles

Acanthamoeba causes diseases such as Acanthamoeba keratitis (AK) which leads to permanent blindness and granulomatous Acanthamoeba encephalitis (GAE) where there is formation of granulomas in the brain. Current treatments such as chlorhexidine, diamidines

Synthesis, molecular docking and xanthine oxidase inhibitory activity of 5-aryl-1H-tetrazoles

5-Aryl-1H-tetrazoles (1–24) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC50 = 2.0 ± 0.01 μM). Six compounds 3, 4, 5, 9, 21, and 24 exhibited significant to weak act

Diisopropylethylammonium acetate (DIPEAc): An efficient and recyclable catalyst for the rapid synthesis of 5-substituted-1H-tetrazoles

A simple and efficient protocol developed for the synthesis of 5-substituted 1H-tetrazole derivatives through [2+3] cycloaddition reaction between benzonitriles and sodium azide using diisopropylethylammonium acetate as a recyclable reaction medium is described. The reactions proceed well at 80 °C and provide the corresponding tetrazoles in good to excellent yields (up to 94% yield). Developed method has notable advantages, such as simple and mild conditions, easy workup, reusability with consistent catalytic activity, and safer alternative to hazardous, corrosive conventional Lewis acid catalysts.

An efficient one-pot protocol for the conversion of benzaldehydes into tetrazole analogs

An efficient protocol has been developed for the one-pot synthesis of tetrazole derivatives in moderate to good yields starting from substituted benzaldehydes and proceeding via non-isolated oxime and nitrile intermediates. The structures of the desired products were confirmed by IR, and NMR spectroscopy as well as mass spectrometry. A plausible reaction mechanism is also discussed.

One-step synthesis of 5-substituted 1 H -Tetrazoles from an aldehyde by reaction with acetohydroxamic acid and sodium azide under Bi(OTf)3 Catalysis

An efficient one-step method for the synthesis of 5-substituted 1H-tetrazoles from aldehydes by reaction with acetohydroxamic acid and sodium azide using bismuth(III) triflate as the catalyst is described. Georg Thieme Verlag Stuttgart · New York.

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli

A series of 33 novel divanillates and trivanillates were synthesized and found to possess promising cytostatic rather than cytotoxic properties. Several compounds under study decreased by >50% the activity of Aurora A, B, and C, and WEE1 kinase activity at concentrations 50 growth inhibitory ones, accounting, at least partly, for their cytostatic effects in cancer cells and to a lesser extent in normal cells. Compounds 6b and 13c represent interesting starting points for the development of cytostatic agents to combat cancers, which are naturally resistant to pro-apoptotic stimuli, including metastatic malignancies.

Oxadiazole compounds containing 4,6-bis-trichloromethyl-S-triazin-2-yl groups, process for their preparation

Compounds of general formula I are disclosed STR1 wherein R1 denotes an unsubstituted or substituted carbocyclic or heterocyclic aryl radical, R2 and R3 are different from each other and either denote a hydrogen atom or a 4,6-bis-trichloromethyl-s-triazin-2-yl group, and n and m independently of each other, denote one of the numbers 0 and 1. The compounds are effective free-radical-forming photoinitiators and photolytically-activatable acid donors for photosensitive compositions.

Synthesis of 5-Aryl-2H-tetrazoles, 5-Aryl-2H-tetrazole-2-acetic Acids, and acetic Acids as Possible Superoxide Scavengers and Antiinflammatory Agents

A series of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction.The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.

Synthesis of 4-Aryl-1-thiosemicarbazides and 5-(3,4-Dimethoxyphenyl)tetrazole-2-acetic Acid Arylidenehydrazides as Potential Antiinflammatory Agents

A series of 4-aryl-1-thiosemicarbazides (IVa-h) and 5-(3,4-dimethoxyphenyl)tetrazole-2-acetic acid arylidenehydrazides (Va-f) have been synthesized by the reaction of 5-(3,4-dimethoxyphenyl)tetrazole-2-acetic ac