10494-75-4

Basic information

• Product Name: 2-methoxyethanethiol
• Synonyms: 2-methoxyethanethiol;1-Mercapto-2-methoxyethane;2-Methoxy-1-ethanethiol
• CAS NO: 10494-75-4
• Molecular Formula: C₃H₈OS
• Molecular Weight: 92.16002
• EINECS: 234-021-3
• Mol File: 10494-75-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 108.5°Cat760mmHg
• Flash Point: 19.4°C
• Appearance: /
• Density: 0.935g/cm³
• Vapor Pressure: 30.3mmHg at 25°C
• Refractive Index: 1.432
• CAS DataBase Reference: 2-methoxyethanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxyethanethiol(10494-75-4)
• EPA Substance Registry System: 2-methoxyethanethiol(10494-75-4)

Safety Data

• Hazardous Substances Data: 10494-75-4(Hazardous Substances Data)

Usage

General Description

2-Methoxyethanethiol is a chemical compound with the molecular formula C3H8OS. It is a colorless liquid with a strong, unpleasant odor, resembling that of boiled cabbage. It is commonly used as a flavoring agent in food and beverages, and as a fragrance in cosmetic and personal care products. It is also used as a solvent and as a chemical intermediate in the production of various other chemicals. 2-Methoxyethanethiol is highly flammable and can cause irritation to the skin, eyes, and respiratory system upon exposure, and should be handled and stored with caution.

InChI:InChI=1/C3H8OS/c1-4-2-3-5/h5H,2-3H2,1H3

Upstream product

• 6482-24-2 2-Bromoethyl methyl ether 
• 627-42-9 2-chloroethyl methyl ether 
• 17178-10-8 2-methoxy-ethyl p-toluenesulfonyloxy ester 
• 186581-53-3 diazomethane 
• 60-24-2 2-hydroxyethanethiol 
• 64743-40-4 1-(2-methoxy-ethylsulfanyl)-ethanol 
• 95966-75-9 S-2-methoxyethyl thioacetate 

Downstream Products

• 25756-33-6 2-hydroxyethyl 2-methoxyethyl sulfide 
• 1185188-95-7 4-(3,5-dimethylpheoxy)-3-iodo-5-(2-methoxy-ethylthiomethyl)-6-methylpyridin-2(1H)-one 
• 1229649-32-4 N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)methyl)pyridin-2-yl)-2-(2-methoxyethylthio)acetamide 
• 1610546-24-1 tert-butyl-{3-[((2-methoxyethyl)sulfanyl)methyl]-5-(trifluoromethyl)phenyl}carbamate 
• 1088713-31-8 3-(2-methoxyethyl)thio-2-methyl-4-trifluoromethylbenzoic acid 
• 87028-94-2 2-(2-methoxyethylthio)benzenesulfonamide 
• 35740-31-9 2-Methoxyethyl-2',4'-dinitrophenyl-disulfid 
• 83344-33-6 4-Acetoxy-3-(2-methoxy-ethylsulfanyl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 83344-51-8 3-(2-Methoxy-ethylsulfanyl)-4-methylcarbamoyloxy-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 83344-44-9 4-Hydroxy-3-(2-methoxy-ethylsulfanyl)-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 63875-72-9 Benzyl-2-methoxyethyl-disulfid 

Relevant articles and documents

Solid phase synthesis of oligoethylene glycol-functionalized quinolinecarboxamide foldamers with enhanced solubility properties

A series of octameric quinoline oligoamide foldamers has been synthesized consisting exclusively of monomers which display mono-, di-, tri- or tetra-ethylene glycol side-chains. These oligomers adopt stable helical conformations. New Fmoc-acid monomer precursors were first developed. The microwave assisted solid-phase synthesis (SPS) methodology for oligomer preparation is described, and it is demonstrated that small adjustments in side-chain length translate into large differences in the solubility profile of the oligomers. The impact of such modifications on foldamer preparation, handedness inversion kinetics and potential applications is also discussed.

Cationic [99mTcIII(DIARS)2(SR)2]+ complexes as potential myocardial perfusion imaging agents (DIARS = o-phenylenebis(dimethylarsine);SR- = thiolate).

Reduction-substitution reactions on [99mTcO4]- with both o-phenylenebis(dimethylarsine) (DIARS) and various thiols produce a series of monocationic [99Tc(DIARS)2(SR)2]+ complexes. Addition of [99gTcO4]- to the above reaction mixtures allows the characterization of the "carrier-added" complexes by means of reverse-phase high-performance liquid chromatography with radiometric and optical detection systems. The identity of the [99mTc(DIARS)2(SR)2]+ complexes is confirmed by fast atom bombardment mass spectroscopy; equivalence of the [99gTc(DIARS)2-(SR)2]+ and [99mTc(DIARS)2(SR)2]+ species is demonstrated by identical HPLC retention times. All the [99mTc(DIARS)2(SR)2]+ complexes tested accumulate in the myocardium of Sprague-Dawley rats with an average uptake of 1.5-2.0% of injected dose/g at 30 min. Thus, as designed, these nonreducible Tc(III) complexes do not exhibit the rapid myocardial washout observed for reducible Tc(III) complexes. These [99mTc(DIARS)2(SR)2]+ complexes also exhibit an initially high liver uptake, but the presence of ether groups within the thiolate ligands causes this liver uptake to decrease over time without affecting the heart uptake, thereby improving the heart/liver ratio.

As tyrosine kinase inhibitors of the nitrogen-containing heteroaromatic ring derivatives

The present invention relates to compounds as represented by general formula (I) as tyrosine kinase inhibitors, preparation method thereof, pharmaceutical compositions containing the compounds, and uses thereof for preventing and/or treating instances of B-cell related leukemia, inflammatory diseases and autoimmune diseases, wherein A, ring B, L1, L2, R1, R2, R3, a, b, c, d, e, p and q are as defined in the specification.