10496-93-2

Basic information

• Product Name: 4-(hydroxymethyl)-2,5-dimethylphenol
• Synonyms: 4-(hydroxymethyl)-2,5-dimethylphenol
• CAS NO: 10496-93-2
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19038
• Mol File: 10496-93-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(hydroxymethyl)-2,5-dimethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(hydroxymethyl)-2,5-dimethylphenol(10496-93-2)
• EPA Substance Registry System: 4-(hydroxymethyl)-2,5-dimethylphenol(10496-93-2)

Safety Data

• Hazardous Substances Data: 10496-93-2(Hazardous Substances Data)

Upstream product

• 95-87-4 2,5-Dimethylphenol 
• 50-00-0 formaldehyd 
• 7732-18-5 water 
• 121-44-8 triethylamine 
• 75-50-3 trimethylamine 

Downstream Products

• 103391-94-2 2-(4-hydroxymethyl-2,5-dimethyl-phenoxymethyl)-5-methoxy-pyran-4-one 
• 725234-07-1 4-chloromethyl-2,5-dimethyl-anisole 
• 858217-12-6 2-(4-methoxy-2,5-dimethyl-benzyl)-3-methyl-butyric acid 
• 855657-53-3 isopropyl-(4-methoxy-2,5-dimethyl-benzyl)-malonic acid diethyl ester 
• 147351-67-5 2,5-dimethyl-4-(phenylmethoxy)benzenemethanol 
• 85231-15-8 4-formyl-2,5-dimethylphenol 
• 85430-29-1 4-methoxy-2,5-dimethyl-benzyl alcohol 
• 854179-47-8 4-(2-hydroxy-ethoxy)-2,5-dimethyl-benzyl alcohol 

Relevant articles and documents

Phenolic Oxidation Using H2O2 via in Situ Generated para-Quinone Methides for the Preparation of para-Spiroepoxydienones

Phenols are attractive starting materials for the preparation of highly substituted cyclohexane rings via dearomative processes. Herein we report an efficient preparation of dearomatized 1-oxaspiro[2.5]octa-4,7-dien-6-ones (para-spiroepoxydienones) via the nucleophilic epoxidation of in situ generated para-quinone methides from 4-(hydroxymethyl)phenols using aqueous H2O2. The developed protocol bypasses the need for stoichiometric bismuth reagents or diazomethane, which are frequently deployed for p-spiroepoxydienone preparation. The p-spiroepoxydienones are further elaborated in numerous downstream complexity-building transformations.

4-oxy-substituted phenoxyalkyl carboxylic acid, ester, and alcohol derivatives as antihyper-cholesterolemic and antiatherosclerotic agents

Novel 4-oxy substituted phenoxyalkyl carboxylic acid, ester and alcohol derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.