1049677-32-8

Basic information

• Product Name: 8-Chloro-3-iodoimidazo[1,2-a]pyrazine
• Synonyms: 8-Chloro-3-iodoimidazo[1,2-a]pyrazine
• CAS NO: 1049677-32-8
• Molecular Formula: C₆H₃ClIN₃
• Molecular Weight: 279.46559
• Mol File: 1049677-32-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 2.34
• CAS DataBase Reference: 8-Chloro-3-iodoimidazo[1,2-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro-3-iodoimidazo[1,2-a]pyrazine(1049677-32-8)
• EPA Substance Registry System: 8-Chloro-3-iodoimidazo[1,2-a]pyrazine(1049677-32-8)

Safety Data

• Hazardous Substances Data: 1049677-32-8(Hazardous Substances Data)

Usage

General Description

The chemical 8-chloro-3-iodoimidazo[1,2-a]pyrazine is an organic compound with a molecular formula C5H3ClIN3. It is a heterocyclic compound that contains both chlorine and iodine atoms, along with an imidazole and pyrazine ring system. 8-chloro-3-iodoimidazo[1,2-a]pyrazine is used in pharmaceutical research and is being investigated for its potential medicinal properties, including its potential as an anti-cancer and anti-inflammatory agent. Its unique structure and properties make it a valuable tool for understanding the reactivity and biological activity of similar compounds. Additionally, it is used as a building block in the synthesis of various organic molecules in the field of medicinal chemistry.

Upstream product

• 69214-33-1 8-chloroimidazo[1,2-α]pyrazine 
• 105076-76-4 N-(4-amino-phenyl)-2-(morpholin-4-yl)-acetamide 
• 262368-13-8 2-morpholin-4-yl-N-(4-nitro-phenyl)-acetamide 

Downstream Products

• 1383104-88-8 4-(8-Chloroimidazo[1,2-a]pyrazin-3-yl)-N-cyclopropylbenzamide 
• 1383102-70-2 N-cyclopropyl-4-(8-{[2-(methylsulfonyl)ethyl]amino}imidazo[1,2-a]pyrazin-3-yl)benzamide 

Relevant articles and documents

NOVEL IMIDAZO-PYRAZINE DERIVATIVES

The invention provides novel imidazo-pyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, m, n, and R1to R3 are as described herein: formula (I). Further provided are pharmace

Novel and selective TLR7 antagonists among the imidazo[1,2- a]pyrazines, Imidazo[1,5- a]quinoxalines, and Pyrazolo[1,5- a]quinoxalines Series

The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system activation, and their agonists may therefore serve as promising candidate vaccine adjuvants. However, the chronic immune activation by excessive TLR stimulation is a hallmark of several clinically important infectious and autoimmune diseases, which warrants the search for TLR antagonists. In this study, we have synthesized and characterized a variety of compounds belonging to three heterocyclic chemical series: imidazo[1,2-a]pyrazine, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline. These compounds have been tested for their TLR7 or TLR8 agonistic and antagonistic activities. Several of them are shown to be selective TLR7 antagonists without any TLR7 or TLR8 agonistic activity. The selectivity was confirmed by a comparative ligand-docking study in TLR7 antagonist pocket. Two compounds of the pyrazolo[1,5-a]quinoxaline series (10a and 10b) are potent selective TLR7 antagonists and may be considered as promising starting points for the development of new therapeutic agents.

IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS

The present invention relates to substituted imidazopyrazine compounds of general formula (I) : in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.