104968-70-9

Basic information

• Product Name: (S,S)-reboxetine (S)-mandelate
• Synonyms: (S,S)-reboxetine (S)-mandelate
• CAS NO: 104968-70-9
• Molecular Weight: 465.546
• Mol File: 104968-70-9.mol

Chemical Properties

• CAS DataBase Reference: (S,S)-reboxetine (S)-mandelate(CAS DataBase Reference)
• NIST Chemistry Reference: (S,S)-reboxetine (S)-mandelate(104968-70-9)
• EPA Substance Registry System: (S,S)-reboxetine (S)-mandelate(104968-70-9)

Safety Data

• Hazardous Substances Data: 104968-70-9(Hazardous Substances Data)

Upstream product

• 98819-74-0 N-[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]-2-chloroacetamide 
• 1340546-27-1 (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate 
• 17199-29-0 (S)-Mandelic acid 
• 98819-77-3 (+)-(2S,3S)-2-<α-(2-ethoxyphenoxy)benzyl>morpholine methanesulfonate 
• 71620-89-8 (S,S)-reboxetine 
• 98819-73-9 (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 93851-63-9 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 93853-04-4 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate 
• 98769-69-8 (2RS,3SR)-3-(2-ethoxyphenoxy)-1,2-dihydroxy-3-phenylpropane 
• 93851-63-9 (2RS,3SR)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 40641-81-4 trans-2,3-epoxy-3-phenylpropan-1-ol 
• 94-71-3 2-Ethoxyphenol 
• 93852-40-5 (2RS,3SR)-1-chloroacetylamino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 

Downstream Products

• 635724-55-9 (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate 

Relevant articles and documents

Commercial synthesis of (S,S)-reboxetine succinate: A journey to find the cheapest commercial chemistry for manufacture

The development of a synthetic process for (S,S)-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination. This entailed evaluation of several alternative routes to result in what would have been a commercially attractive process for launch of the compound.