1049685-54-2Relevant academic research and scientific papers
Room temperature ICl-induced dehydration/iodination of 1-acyl-5-hydroxy-4, 5-dihydro-1H-pyrazoles. A selective route to substituted 1-acyl-4-iodo-1H- pyrazoles
Waldo, Jesse P.,Mehta, Saurabh,Larock, Richard C.
, p. 6666 - 6670 (2008)
(Chemical Equation Presented) A number of new functionally substituted 1-acyl-5-hydroxy-4,5-dihydro-1H-pyrazoles have been prepared in moderate to excellent yields from the corresponding 2-alkyn-1-ones. The resulting dihydropyrazoles undergo dehydration and iodination in the presence of ICl and Li2CO3 at room temperature to provide 1-acyl-4-iodo-1H- pyrazoles.
