1049801-59-3Relevant academic research and scientific papers
NEW SUBSTITUTED N9-ADENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF
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Paragraph 0031, (2021/05/06)
The invention provides new substituted N9-adenine derivatives, pharmaceutical compositions containing these derivatives and the use of the new derivatives and the pharmaceutical compositions containing same as AMPK activators, being suitable for the production of drugs for the treatment of disorders and diseases where AMPK activation plays a relevant role.
Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction
Morellato, Laurence,Huteau, Valérie,Pochet, Sylvie
, p. 1625 - 1627 (2014/03/21)
A series of 9-(hetero)arylpurine derivatives has been prepared through N-arylation of 6-chloropurine with boronic acids in the presence of copper(II) acetate. Screening reaction conditions in terms of bases and solvents led to the successful coupling of a series of sterically demanding (hetero)arylboronic acids, never described so far. The coupling products were next readily converted into the target adenine derivatives. The described procedure provides easy access to original fragments for screening applications. Moreover these 9-aryl-6-chloropurine derivatives might be useful as intermediates for the preparation of purine derivatives with potential biological properties.
A mild and efficient method for N-arylnucleobase synthesis via the cross-coupling reactions of nucleobases with arylboronic acids catalyzed by simple copper salts
Tao, Lan,Yue, Yang,Zhang, Ji,Chen, Shan-Yong,Yu, Xiao-Qi
scheme or table, p. 1008 - 1014 (2009/02/07)
A simple and efficient copper-salt catalyzed N-arylation of nucleobases is reported. In a mixed solvent of MeOH and H2O, the coupling products were obtained in moderate to excellent yields at room temperature within a short time. Avariety of su
