10500-08-0Relevant academic research and scientific papers
Highly enantioselective Rh-catalysed hydrogenation of 1-alkyl vinyl esters using phosphine-phosphoramidite ligands
Konrad, Tina Maria,Schmitz, Pascal,Leitner, Walter,Francio, Giancarlo
supporting information, p. 13299 - 13303 (2013/10/08)
MatPhos, a good mate for hard tasks: The asymmetric hydrogenation of 1-alkyl vinyl esters, thwarted so far by mediocre ee values and low activities, can now be achieved with MatPhos/Rh catalysts with ee values of 96-99 % for a variety of substrates at low catalyst loadings (0.1-1 mol %) and under mild conditions (5-20 bar H2, room temperature). After hydrolysis, the corresponding chiral secondary alkyl alcohols can be obtained in high enantiopurities providing a general and practical route to this important product class. Copyright
Indole-2-carboxamide derivatives useful as beta-2 agonists
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Page 42, (2010/02/08)
The invention relates to indole derivatives of general formula: and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions. In particular inflammatory, allergic and respiratory diseases, disorders and conditions.
Arylation and 1-Alkenylation on α-Position of Ketones via Tributyltin Enolates Catalyzed by Palladium Complex
Kosugi, Masanori,Hagiwara, Isao,Sumiya, Takao,Migita, Toshihiko
, p. 241 - 246 (2007/10/02)
The reaction of tributyltin enolates, prepared from tributyltin methoxide and enol acetates in situ, with aryl and 1-alkenyl bromides in the presence of dichlorobis(tri-o-tolylphosphine)palladium was found to give α-aryl and α-(1-alkenyl) ketones, respectively, in good yields with essentially complete retention of the enol acetate regiochemistry.
Process for the preparation of unsaturated ketones
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, (2008/06/13)
Ketones, which are intermediates in the synthesis of vitamin A or perfumes, and have the general formula: EQU1 wherein R1 is hydrogen or C1-10 hydrocarbon, R2 and R3 are hydrogen or C1-4 alkyl, R4 and R5 are hydrogen or together form a --CH2 --CH2 --C(CH3)2 -- group, R6 and R7 are hydrogen or C1-10 hydrocarbon, or together with the carbon atom to which they are joined form a hydrocarbon ring of up to 10 carbons, or EQU2 forms a hydrocarbon ring of up to 10 carbons joined through R6 and R8 or R7 and R8, R8 is hydrogen or C1-10 hydrocarbon and n is 0-6, are prepared by reacting an unsaturated halide of formula EQU3 wherein X is halogen, with an enol ester of formula EQU4 wherein R9 is C1-20 hydrocarbon, in the presence of a metal catalyst.
