1050324-77-0Relevant academic research and scientific papers
An expedient synthesis of 6-arylpiperidine-2,4-diones by chain-extension of β-aryl-β-aminoacids
Leflemme, Nicolas,Dallemagne, Patrick,Rault, Sylvain
, p. 8997 - 8999 (2001)
The synthesis of novel 6-arylpiperidine-2,4-diones is described in five steps starting from β-aryl-β-aminoacids via the chain extension of the latter into δ-aryl-δ-amino-β-ketoacids. The chemical pathway involves an acylation of Meldrum's acid and yields useful building blocks for heterocyclic chemistry.
Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI)
Wu, Dongpei,Pontillo, Joseph,Ching, Brett,Hudson, Sarah,Gao, Yinghong,Fleck, Beth A.,Gogas, Kathleen,Wade, Warren S.
scheme or table, p. 4224 - 4227 (2009/04/10)
The design, synthesis, and SAR of a series of ring-constrained norepinephrine reuptake inhibitors are described. A substantially rigid inhibitor with potent functional activity at the transporter (IC50 = 8 nM) was used to develop a model for th
