1050329-20-8Relevant articles and documents
Novel Multiple Type Molecular Targeted Antitumor Agents: Preparation and Preclinical Evaluation of Low-Molecular-Weight Phospha Sugar Derivatives
Makita, Reiko,Yamashita, Mitsuji,Yamaoka, Mayumi,Fujie, Michio,Nakamura, Satoki,Oshikawa, Tatsuo,Yamashita, Junko,Yamada, Manabu,Asai, Kazuhide,Suyama, Takuya,Kondo, Mitsuru,Hasegawa, Hiroko,Okita, Yoshimitsu,Hirakawa, Kazutaka,Toda, Mitsuo,Ohnishi, Kazunori,Sugimura, Haruhiko
, p. 733 - 740 (2016/01/15)
Phospha sugar derivatives of 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide and 2,3,4-tribromo-3-methyl-1-phenylphospholane 1-oxide were synthesized from 2-phospholenes and evaluated by in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide method against leukemia cell lines, and then characterized by cell cycle analysis, Western blot analysis, and molecular docking simulation. Phospha sugar derivatives were revealed to be potential antitumor agents against leukemia cell lines such as U937 and K562. Cell cycle analysis indicated that phospha sugar derivatives induced apoptoses. Western blot analyses against U937 showed that phospha sugar derivatives regulate many mitotic regulators in cell cycle. Results of molecular docking simulation suggested that phospha sugar derivatives enter the pockets present in cell cycle and apoptosis-related proteins.
Synthesis of Some 1-aryl-2,3-dibromophospholanes as novel anti-cancer agents
Yamada, Manabu,Asai, Kazuhide,Yamashita, Junko,Suyama, Takuya,Niimi, Taishi,Maddali, Kasthuraiah,Fujie, Michio,Nakamura, Satoki,Kimura, Motohiko,Tanaka, Yasutaka,Toda, Mitsuo,Yamashita, Mitsuji
, p. 173 - 180 (2011/06/24)
Novel phosphorus heterocyclic compounds, 3-methyl-1-(3-bromophenyl as well as some 3-substituted phenyl)-2- phospholene 1-oxides (1d as well as 1b, 1c, and 1f), were synthesized from 1-phenyl-2-phospholene 1-oxide 1a via 3-methyl-1-(3-nitrophenyl)-2-phospholene 1-oxide (1b). 1-(4-Bromophenyl)-2- phospholene 1e was prepared by Grignard coupling reaction of 1-chloro-3-methyl-2-phospholene 1-oxide with 4-bromophenylmagnesium bromide. 2,3-Dibromo-3-methyl-1-arylphospholane 1-oxides (2a-2e) were prepared by the addition reaction of bromine to the C=C double bond of 2-phospholenes 1a-1e. The substituent effect of the phenyl group of the 1-aryl-phospho lanes 2 on the observed anti-proliferative effect against U937 leukemia cell lines evaluated by MTT in vitro methods showed that 2,3-dibromo-3-methyl-1-(4-bromophenyl) phospholane (2e) was the most active among 2. These novel dibromophosphorus heterocyclic derivatives exhibit much higher anti-cancer activity than Gleevec (molecular targeting chemotherapeutic agent) against U937 cells.
Preparation and characterization of phospholanes and phospha sugars as novel anti-cancer agents
Ito, Satoru,Yamashita, Mitsuji,Niimi, Taishi,Fujie, Michio,Reddy, Valium Krishna,Totsuka, Hirono,Haritha, Buchammagari,Maddali, Kasthuraiah,Nakamura, Satoki,Asai, Kazuhide,Suyama, Takuya,Yamashita, Junko,Iguchi, Yukiko,Yu, Gang,Oshikawa, Tatsuo
experimental part, p. 23 - 30 (2010/03/03)
Diastereo isomeric erythro and threo forms of 2, 3-epoxy-l- phenylphospholane 1-oxides were synthesized from threo and erythro forms of 2-bromo-3-hydroxy-l-phenylphospholane 1-oxides being prepared from l-phenyl-2-phospholene 1-oxide. Alternatively, the e
