10504-94-6

Basic information

• Product Name: 4-chloro-N-(4-methylbenzyl)benzenesulfonamide
• Synonyms: 4-chloro-N-(4-methylbenzyl)benzenesulfonamide
• CAS NO: 10504-94-6
• Molecular Formula: C₁₄H₁₄ClNO₂S
• Molecular Weight: 295.78446
• Mol File: 10504-94-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-chloro-N-(4-methylbenzyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(4-methylbenzyl)benzenesulfonamide(10504-94-6)
• EPA Substance Registry System: 4-chloro-N-(4-methylbenzyl)benzenesulfonamide(10504-94-6)

Safety Data

• Hazardous Substances Data: 10504-94-6(Hazardous Substances Data)

Upstream product

• 98-64-6 4-Chlorobenzenesulfonamide 
• 104-87-0 4-methyl-benzaldehyde 
• 468080-03-7 4-chloro-N-(4-methylbenzylidene)benzenesulfonamide 
• 37100-89-3 4-chloro-benzenesulfonic acid p-tolyl ester 
• 104-84-7 para-methylbenzylamine 
• 80-33-1 chlorofensone 
• 26971-85-7 p-Nitrophenyl p-chlorobenzenesulphonate 
• 2437-33-4 4-chlorobenzolsulfonsaeure-phenylester 

Relevant articles and documents

Amide Iridium Complexes As Catalysts for Transfer Hydrogenation Reduction of N-sulfonylimine

Sulfonamide moieties widely exist in natural products, biologically active substance, and pharmaceuticals. Here, an efficient water-soluble amide iridium complexes-catalyzed transfer hydrogenation reduction of N-sulfonylimine is developed, which can be carried out under environmentally friendly conditions, affording a series of sulfonamide compounds in excellent yields (96-98%). In comparison with organic solvents, water is shown to be critical for a high catalytic transfer hydrogenation reduction in which the catalyst loading can be as low as 0.001 mol %. These amide iridium complexes are easy to synthesize, one structure of which was determined by single-crystal X-ray diffraction. This protocol gives an operationally simple, practical, and environmentally friendly strategy for synthesis of sulfonamide compounds.

Synthesis process of sulfonamide compounds in microwave system

The invention discloses a synthesis process of sulfonamide compounds in a microwave system. The synthesis process is realized by the following steps: by using CuCl as a catalyst and FeCl3 as an oxidant, carrying out carbon-hydrogen activating and carbon-nitrogen coupling reaction in a DMF (Dimethyl Formamide) by substituting sulfanilamide and methylbenzene through microwave heating and efficient catalysis for 10 to 60 minutes; extracting a product by using ethyl acetate; carrying out vacuum concentration; carrying out column chromatographic purification on a product to obtain the sulfonamide compounds. The synthesis process is a method for efficiently preparing the sulfonamide compounds, which is environment-friendly and is simple and convenient to operate. Compared with the prior art, the synthetic process disclosed by the invention has the advantages of remarkably-increased reaction speed compared with that under a conventional heating condition, mild reaction conditions, simple operation, high yield, safety, low cost and environmental protection.