1050443-38-3Relevant academic research and scientific papers
General and practical conversion of aldehydes to homologated carboxylic acids
Cafiero, Lauren R.,Snowden, Timothy S.
supporting information; experimental part, p. 3853 - 3856 (2009/07/01)
(Chemical Equation Presented) The reaction of aldehydes with trichloromethide followed by sodium borohydride or sodium phenylseleno(triethyl) borate under basic conditions affords homologated carboxylic acids in high yields. This operationally simple procedure provides a practical, efficient alternative to other homologation protocols. The approach is compatible with sensitive aldehydes including enals and enolizable aldehydes. It also offers convenient access to α-monodeuterated carboxylic acids.
