1050504-40-9

Upstream product

• 1050504-33-0 [(3S,4R)-4-(t-butoxycarbonylamino)-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-yl]methyl benzoate 
• 76-05-1 trifluoroacetic acid 
• 1050504-31-8 t-butyl [(3R,4S)-4-(hydroxymethyl)-1-[(S)-1-phenylethyl]pyrrolidin-3-yl]carbamate 
• 1050504-32-9 [(3S,4R)-4-(t-butoxycarbonylamino)pyrrolidin-3-yl]methyl benzoate 
• 1050504-29-4 [(3S,4R)-4-amino-1-[(S)-1-phenylethyl]pyrrolidin-3-yl]methanol 
• 1050504-30-7 (3R,4S,1'S)-3-(t-butoxycarbonylamino)-4-(hydroxymethyl)-1-(1-phenylethyl)pyrrolidine 

Downstream Products

• 1050504-41-0 [(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate 

Relevant academic research and scientific papers

Analogues of nucleosides: Synthesis of chiral pyrrolidin-2-ones or pyrrolidines-bearing nucleobases

Novel analogues of nucleosides tethered on a chiral pyrrolidin-2-one were prepared, but the imide functionality was unstable under basic conditions. Thus, the carbonyl group was removed from pyrrolidin-2-one, and nucleoside analogues bearing a pyrrolidine ring were synthesized, which were unaffected under basic conditions. A nucleoside dimer was also obtained, bearing a carbamate linkage between two units.

NEW SYNTHONS FOR THE SYNTHESIS OF CHIRAL PEPTIDE NUCLEIC ACIDS AND METHODS FOR PREPARING THE SAME

Novel l-acyl-3-amino-4-hydroxymethylpyiτolidine derivatives useful as PNA synthons optionally having protecting groups suitable of removal under mild conditions are disclosed having the formula (E) wherein: R1 is H or R-C(=O), wherein R is stra