1050504-41-0

Upstream product

• 1050504-38-5 (3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine 
• 1050504-40-9 (3R,4S)-4-[(benzoyloxy)methyl]-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-aminium 2,2,2-trifluoroacetate 
• 1050504-30-7 (3R,4S,1'S)-3-(t-butoxycarbonylamino)-4-(hydroxymethyl)-1-(1-phenylethyl)pyrrolidine 
• 1050504-29-4 [(3S,4R)-4-amino-1-[(S)-1-phenylethyl]pyrrolidin-3-yl]methanol 
• 1050504-37-4 t-butyl [(3R,4S)-4-(hydroxymethyl)-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-yl]carbamate 
• 1613255-81-4 t-butyl [(3R,4S)-4-(hydroxymethyl)-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-yl]carbamate 
• 1050504-33-0 [(3S,4R)-4-(t-butoxycarbonylamino)-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-yl]methyl benzoate 
• 1050504-32-9 [(3S,4R)-4-(t-butoxycarbonylamino)pyrrolidin-3-yl]methyl benzoate 
• 1050504-31-8 t-butyl [(3R,4S)-4-(hydroxymethyl)-1-[(S)-1-phenylethyl]pyrrolidin-3-yl]carbamate 

Relevant academic research and scientific papers

Analogues of nucleosides: Synthesis of chiral pyrrolidin-2-ones or pyrrolidines-bearing nucleobases

Novel analogues of nucleosides tethered on a chiral pyrrolidin-2-one were prepared, but the imide functionality was unstable under basic conditions. Thus, the carbonyl group was removed from pyrrolidin-2-one, and nucleoside analogues bearing a pyrrolidine ring were synthesized, which were unaffected under basic conditions. A nucleoside dimer was also obtained, bearing a carbamate linkage between two units.

NEW SYNTHONS FOR THE SYNTHESIS OF CHIRAL PEPTIDE NUCLEIC ACIDS AND METHODS FOR PREPARING THE SAME

Novel l-acyl-3-amino-4-hydroxymethylpyiτolidine derivatives useful as PNA synthons optionally having protecting groups suitable of removal under mild conditions are disclosed having the formula (E) wherein: R1 is H or R-C(=O), wherein R is stra