105064-22-0Relevant academic research and scientific papers
Rapid Access to a Series of Highly Functionalized α,β-Unsaturated Cyclopentenones. A Caveat on Aminospirocyclization
Conrad, P. C.,Kwiatkowski, P. L.,Fuchs, Philip L.
, p. 586 - 591 (2007/10/02)
Conjugate addition of a series of functionalized aryllithium reagents to cyclopentenyl sulfones 9 and 17 results in α-sulfonyl anion intermediates taht are further alkylated to afford triply converged adducts 12a-c and 19.Refunctionalization of these adducts provides α,β-unsaturated cyclopentenones 4a-c and 21 in high overall yields.Attempted intramolecular Michael addition of these (γ-aminopropyl)cyclopentenones to produce the spiro ring system was unsuccessful.
