1050654-20-0Relevant academic research and scientific papers
Copper mediated atom transfer radical cyclisations with AIBN
Clark, Andrew J.,Wilson, Paul
, p. 4848 - 4850 (2008)
We have shown that it is possible to mediate a range of 5-exo trig and 5-exo dig atom transfer radical cyclisations of bromoacetamides using 0.1-1 mol % CuBr or CuBr2 in conjunction with 0.1-1 mol % tri(pyridin-2-ylmethyl)amine and 10 mol % AIBN. This equates to a 30-300-fold reduction in the amount of catalyst previously reported for these reactions and allows cyclisation to be carried out with the more oxidatively stable CuBr2 without the requirement of an inert atmosphere.
