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Ro 51, also known as Ro 51-7824, is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3. These purinoceptor subtypes have been shown to play a crucial role in various pain conditions, making Ro 51 a promising candidate for the treatment of pain.

1050670-85-3

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1050670-85-3 Usage

Uses

Used in Pharmaceutical Industry:
Ro 51 is used as a dual antagonist for the treatment of pain conditions. The antagonist acts on purinoceptor subtypes P2X3 and P2X2/3, which are pivotal in various pain models. By targeting these receptors, Ro 51 has the potential to alleviate pain and improve the quality of life for patients suffering from different types of pain.

Check Digit Verification of cas no

The CAS Registry Mumber 1050670-85-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,0,6,7 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1050670-85:
(9*1)+(8*0)+(7*5)+(6*0)+(5*6)+(4*7)+(3*0)+(2*8)+(1*5)=123
123 % 10 = 3
So 1050670-85-3 is a valid CAS Registry Number.

1050670-85-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-{[4-Amino-5-(5-iodo-2-isopropyl-4-methoxyphenoxy)-2-pyrimidinyl ]amino}-1,3-propanediol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1050670-85-3 SDS

1050670-85-3Downstream Products

1050670-85-3Relevant academic research and scientific papers

Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain

Jahangir, Alam,Alam, Muzaffar,Carter, David S.,Dillon, Michael P.,Bois, Daisy Joe Du,Ford, Anthony P.D.W.,Gever, Joel R.,Lin, Clara,Wagner, Paul J.,Zhai, Yansheng,Zira, Jeff

scheme or table, p. 1632 - 1635 (2009/10/15)

The purinoceptor subtypes P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions. Identification of a potent and selective dual P2X3/P2X2/3 diaminopyrimidine antagonist RO-4

Diaminopyrimidines as P2X3 and P2X2/3 modulators

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Page/Page column 20, (2008/12/08)

Compounds of formula (I): wherein R1 and R2 are as defined herein. Also disclosed are methods of making and using the subject compounds.

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