105099-94-3

Upstream product

• 30924-93-7 Boc-Glu-OBn 
• 124126-67-6 α-tert-butyl 4-amino-4-deoxy-10-deazapteroyltriglutamate 
• 33047-42-6 4-<(2,4-diaminopteridin-6-yl)ethyl>benzoic acid 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 124126-68-7 α-tert-butyl N-<(9-fluorenylmethoxy)oxy>carbonyl-L-glutamic anhydride 

Relevant academic research and scientific papers

Synthesis and biological evaluation of poly-γ-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin

The chemical synthesis of a series of poly-γ-glutamyl metabolites of the experimental anticancer drugs 10-deazaaminopterin (10-DAAM) and 10-ethyl-10-deazaaminopterin (10-EDAAM) has been carried out by the solid-phase procedure. The synthetic products were

Folate analogues. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cel

Representative examples of folate and antifolate poly-γ-glutamyl metabolites were synthesized via the [(9-fluorenylmethoxy)oxy]carbonyl (Fmoc) chemistry using the KH polyamide resin. Polyglutamate yields were consistently better in all cases compared to t