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1051372-60-1

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1051372-60-1 Usage

Description

6-Chloroquinolin-3-amine, a chloro-substituted derivative of quinolin-3-amine with the molecular formula C9H7ClN2, is a chemical compound that holds significant potential in pharmaceutical and chemical research. Its unique structure and reactivity, coupled with possible biological activity, make it a promising candidate for drug discovery and development. Furthermore, it can be utilized in the synthesis of other organic compounds and as a building block for new materials, marking its importance in the fields of chemistry and pharmaceutical science.

Uses

Used in Pharmaceutical Research and Development:
6-Chloroquinolin-3-amine is used as a pharmaceutical intermediate for its potential biological activity, which may contribute to the development of new drugs. Its unique structure allows for further chemical modifications to enhance its therapeutic properties.
Used in Chemical Research:
In the realm of chemical research, 6-Chloroquinolin-3-amine serves as a valuable compound for studying its reactivity and exploring its potential applications in various chemical reactions.
Used in Organic Synthesis:
6-Chloroquinolin-3-amine is used as a building block in organic synthesis, enabling the creation of a wide range of organic compounds with diverse applications.
Used in Material Science:
As a component in the development of new materials, 6-Chloroquinolin-3-amine may contribute to the design and synthesis of innovative materials with unique properties for various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 1051372-60-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,1,3,7 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1051372-60:
(9*1)+(8*0)+(7*5)+(6*1)+(5*3)+(4*7)+(3*2)+(2*6)+(1*0)=111
111 % 10 = 1
So 1051372-60-1 is a valid CAS Registry Number.

1051372-60-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Chloroquinolin-3-amine

1.2 Other means of identification

Product number -
Other names 6-chloroquinolin-3-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1051372-60-1 SDS

1051372-60-1Upstream product

1051372-60-1Relevant articles and documents

Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB 2) agonists

Cheng, Yuan,Albrecht, Brian K.,Brown, James,Buchanan, John L.,Buckner, William H.,DiMauro, Erin F.,Emkey, Renee,Fremeau Jr., Robert T.,Harmange, Jean-Christophe,Hoffman, Beth J.,Huang, Liyue,Huang, Ming,Lee, Josie Han,Lin, Fen-Fen,Martin, Matthew W.,Nguyen, Hung Q.,Patel, Vinod F.,Tomlinson, Susan A.,White, Ryan D.,Xia, Xiaoyang,Hitchcock, Stephen A.

experimental part, p. 5019 - 5034 (2009/07/19)

The CB2 receptor is an attractive therapeutic target for analgesic and anti-inflammatory agents. Herein we describe the discovery of a novel class of oxadiazole derivatives from which potent and selective CB 2 agonist leads were developed. Initial hit 7 was identified from a cannabinoid target-biased library generated by virtual screening of sample collections using a pharmacophore model in combination with a series of physicochemical filters. 7 was demonstrated to be a selective CB2 agonist (CB2 EC50 = 93 nM, Emax = 98%, CB 1 EC50 > 10 μM). However, this compound exhibited poor solubility and relatively high clearance in rat, resulting in low oral bioavailability. In this paper, we report detailed SAR studies on 7 en route toward improving potency, physicochemical properties, and solubility. This effort resulted in identification of 63 that is a potent and selective agonist at CB2 (EC50 = 2 nM, Emax = 110%) with excellent pharmacokinetic properties.

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