105151-19-7Relevant academic research and scientific papers
Aerobic oxidative amidation of aromatic and cinnamic aldehydes with secondary amines by CuI/2-pyridonate catalytic system
Zhu, Mingwen,Fujita, Ken-Ichi,Yamaguchi, Ryohei
, p. 9102 - 9109,8 (2012)
A simple and convenient CuI/2-pyridonate catalytic system for the oxidative amidation of aldehydes with secondary amines has been developed. With this system, a variety of useful arylamides have been synthesized in moderate to good yields in the presence of small amount of copper catalyst and the pyridonate ligand, generating only water as a coproduct. Synthesis of cinnamamides was also achieved by the reactions of cinnamaldehydes with secondary amines in moderate yields. Air was successfully employed as a green oxidant in this catalytic system, achieving a safe and atom-efficient system for the synthesis of amides.
Enhancing Ligand-Free Fe-Catalyzed Aminocarbonylation of Alkynes by ZrF4
Huang, Zijun,Dong, Yanan,Li, Yudong,Makha, Mohamed,Li, Yuehui
, p. 5236 - 5240 (2019/09/03)
Zirconium fluoride was utilized to promote efficiently iron-catalyzed aminocarbonylation between alkynes and amines without the use of extra ligands. In particular, this new system is applicable to a wide range of amine and alkyne substrates affording α,β-unsaturated amides in good to excellent yields. Preliminary mechanistic studies reveal the activation model involving interactions of ZF4 with both iron catalyst and amine substrates.
