105159-21-5Relevant academic research and scientific papers
A Chemical Model of Thymidylate Synthetase. Formation of a Thymine Derivative via an Exocyclic Methylene Intermediate
Meij, Paul F. C. van der,Lohmann, Ruth D.,Waard, Eduard R. de,Chen, Tjoe B. R. A.,Pandit, Upendra K.
, p. 1229 - 1230 (2007/10/02)
Reaction of 6-aminouracil derivatives with imidazolidines (methylenetetrahydrofolate models), in the presence of acid, gives an exocyclic methylene intermediate which reacts with nucleophiles present in the mixture or can be reduced to a thymine derivative.
