1051899-83-2

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 2613-34-5 2,4-difluoro-3-chloro-aniline 

Downstream Products

• 1051899-84-3 2-chloro-N-(3-chloro-2,4-difluoro-phenyl)-N-methyl-pyrimidin-4-amine 
• 1075215-57-4 N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine 
• 1051896-03-7 N'-(3-chloro-2,4-difluoro-phenyl)-N'-methyl-N-(3-morpholin-4-yl-5-thiomorpholin-4-yl-phenyI)pyrimidine-2,4-diamine 
• 1051896-43-5 N'-(3-chloro-2,4-difluoro-phenyl)-N'-methyl-N-[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]pyrimidine-2,4-diamine 

Relevant academic research and scientific papers

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors

Janus kinases (JAKs) have been demonstrated to be critical in cytokine signaling and have thus been implicated in both cancer and inflammatory diseases. The JAK family consists of four highly homologous members: JAK1-3 and TYK2. The development of small-m

NOVEL PYRIMIDINE DERIVATIVES 698

The invention concerns compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.

N' - (PHENYL) -N- (MORPHOLIN-4-YL-PYRIDIN-2-YL) -PYRIMIDINE-2, 4-DIAMINE DERIVATIVES AS EPHB4 KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE CONDITIONS

The invention concerns pyrimidine com pounds of Formula (I), or a pharmaceutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 are as defined in the descripti