10519-69-4Relevant academic research and scientific papers
NEOPENTYL COMPLEXES OF PALLADIUM
Diversi, P.,Fasce, D.,Santini, R.
, p. 285 - 294 (1984)
New dineopentyl complexes of palladium, with the formula (L2 = dppe, bipy; L = PMe2Ph) have been prepared by the alkylation of the corresponding dichlorides with Mg(CH2CMe3)Br or LiCH2CMe3.Thermal decomposition of these complexes in solution yields 2,2,5,5-tetramethylhexane.The reactions of these compounds with CO and with some electrophiles (Ph3C+, PhCH2Br, HCl) have been investigated.The reaction with CO produces dineopentyl ketone (when L2 = dppe; L = PMe2Ph) or promotes rapid decomposition to 2,2,5,5-tetramethylhexane (when L2 = bipy).The electrophiles (E+) attack the neopentyl ligand to eliminate ECH2CMe3.In the reaction of with PhCH2Br, has been isolated.A palladacyclic analogue of these systems, , has been prepared by the alkylation of with Li(CH2CMe2CMe2CH2)Li.
ETUDES SUR LE MECANISME DE LA METATHESE DES OLEFINES III. INTERMEDIAIRES TUNGSTACYCLOPENTANIQUES ET TUNGSTACYCLOBUTANIQUES
Levisalles, J.,Rudler, H.,Villemin, D.
, p. 69 - 82 (1980)
With a view to understanding the role of the catalyst in olefin metathesis various attempts were made to synthesize possible intermediates of the reaction.No compound was formed which could account satisfactorily for a metathesis reaction under conditions favourable for the formation of tungstacyclopentane.Attempted synthesis of tungstacyclobutane also failed, but gave results which could be interpreted as mimicking metathesis.In spite of this apparent agreement, it is concluded that, if tungstacyclobutanes are actually formed, they are decomposed to tungstacarbene (alkylidenetungsten) and olefins rather than to tungstacyclopentanes, then to olefins.
DERIVATIVES OF RELEBACTAM AND USES THEREOF
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Paragraph 1546-1548, (2020/04/24)
Derivatives of relebactam, therapeutic methods of using the derivatives of relebactam, particularly in combination with β-lactam antibiotics and pharmaceutical compositions thereof are disclosed. The derivatives of relebactam are suitable for oral administration.
AZTREONAM DERIVATIVES AND USES THEREOF
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Paragraph 1267; 1268, (2019/04/18)
Disclosed herein are aztreonam derivatives, therapeutic methods of using the aztreonam derivatives, particularly in combination with β-lactamase inhibitors, and pharmaceutical compositions thereof. The aztreonam derivatives can be administered orally to provide orally bioavailable aztreonam.
Beta-lactamase inhibitors and uses thereof
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Page/Page column 165, (2018/10/24)
β-Lactamase inhibiting compounds, therapeutic methods of using the β-lactamase inhibiting compounds, particularly in combination with β-lactam antibiotics and pharmaceutical compositions thereof are disclosed. The β-lactamase inhibiting compounds are suitable for oral administration.
Synthesis and Conformation of 4,4,5,5-Tetramethyl-1,2-dithiane Mono-S-oxide
Juaristi, Eusebio,Cruz-Sanchez, J. Samuel
, p. 3334 - 3338 (2007/10/02)
The synthesis of the title compound (6), an interesting subject for the study of anomeric and other conformational effects, was attained from ethyl isobutyrate in eight steps, with an overall yield of 11percent.The synthetic route described herein involved the crucial displacement of both neopentylic tosylate groups in 2,2,3,3-tetramethyl-1,4-butanediol ditosylate; while several standard procedures led to the formation of unexpected products, purified potassium thioacetate in hexamethylphosphoramide afforded the required dithioacetate derivative.The mechanistic implications of the well- and bad-behaved reactions are discussed.From the results of variable-temperature NMR experiments it is concluded that the axial conformer of 6 dominates the equilibrium to such an extent that no contribution of the equatorial isomer is recorded.This result sudggests a ΔG0 3.0 kcal/mol for the conformational equilibrium of the parent 1,2-dithiane mono-S-oxide.
