1052114-81-4

Basic information

• Product Name: 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
• Synonyms: 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 5-(4-fluorophenyl)-1,4-dihydro-4-oxo-;5-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-Pyridinecarboxylic acid
• CAS NO: 1052114-81-4
• Molecular Formula: C₁₂H₈FNO₃
• Molecular Weight: 233.1952232
• Mol File: 1052114-81-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 423.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.437±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.34±0.20(Predicted)
• CAS DataBase Reference: 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid(1052114-81-4)
• EPA Substance Registry System: 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid(1052114-81-4)

Safety Data

• Hazardous Substances Data: 1052114-81-4(Hazardous Substances Data)

Usage

General Description

5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid is a chemical compound with a molecular formula C13H9NO4F. It belongs to the class of dihydropyridines, which are widely used as calcium channel blockers in the treatment of hypertension and angina. This particular compound has a 4-fluorophenyl group attached to the 5-position of the dihydropyridine ring, and a carboxylic acid group at the 3-position. It is a key intermediate in the synthesis of various pharmaceutical compounds and may also have potential biological activities. Its structural features make it a valuable synthetic building block for the development of new drugs and materials.

Upstream product

• 1052114-80-3 ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 1175512-08-9 methyl 5-bromo-4-oxo-1,4-dihydropyridine-3-carboxylate 
• 1765-93-1 4-fluoroboronic acid 
• 221121-37-5 4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester 

Downstream Products

• 1052114-76-7 N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449300-95-1 2,2,2-trifluoroethyl 5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxylate 
• 1449299-59-5 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-74-4 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-benzyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449300-96-2 1-(2,2-difluoro-2-methoxyethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 1449299-86-8 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-(2,2-difluoro-2-methoxyethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449301-25-0 1-benzyl-5-(4-fluorophenyl)-4-oxo-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,4-dihydropyridine-3-carboxamide 
• 1449300-20-2 N-[4-(2-amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3-methoxyphenyl}pyridin-3-yl)phenyl]-1-benzyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449300-81-5 5-(4-fluorophenyl)-4-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,4-dihydropyridine-3-carboxylic acid 
• 1449299-67-5 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,4-dihydropyridine-3-carboxamide 
• 1449299-69-7 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449301-84-1 methyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate 
• 1449300-87-1 1-benzyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 1528546-96-4 N-(3-fluoro-4-(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-8-yloxy)phenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 

Relevant articles and documents

QUINOLINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES

Provided herein are compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, R1, R2, R3, R4, R5, R6 and R7 are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.

PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES

Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Formula (I). Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.

4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER

Disclosed are compounds of Formula (I)and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a