1052115-55-5Relevant academic research and scientific papers
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent
Zhu, Gui-Dong,Gandhi, Viraj B.,Gong, Jianchun,Thomas, Sheela,Luo, Yan,Liu, Xuesong,Shi, Yan,Klinghofer, Vered,Johnson, Eric F.,Frost, David,Donawho, Cherrie,Jarvis, Ken,Bouska, Jennifer,Marsh, Kennan C.,Rosenberg, Saul H.,Giranda, Vincent L.,Penning, Thomas D.
, p. 3955 - 3958 (2008)
Poly(ADP-ribose) polymerases (PARPs) play significant roles in various cellular functions including DNA repair and control of RNA transcription. PARP inhibitors have been demonstrated to potentiate the effect of cytotoxic agents or radiation in a number o
