1052146-93-6Relevant articles and documents
Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants
Perni, Robert B.,Farmer, Luc J.,Cottrell, Kevin M.,Court, John J.,Courtney, Lawrence F.,Deininger, David D.,Gates, Cynthia A.,Harbeson, Scott L.,Kim, Joseph L.,Lin, Chao,Lin, Kai,Luong, Yu-Ping,Maxwell, John P.,Murcko, Mark A.,Pitlik, Janos,Rao, B. Govinda,Schairer, Wayne C.,Tung, Roger D.,Van Drie, John H.,Wilson, Keith,Thomson, John A.
, p. 1939 - 1942 (2007/10/03)
We recently described the identification of an optimized α-ketoamide warhead for our series of HCV NS3·4A inhibitors. We report herein a series of HCV protease inhibitors incorporating 3-alkyl-substituted prolines in P2. These compounds show ex
