118758-48-8

Basic information

• Product Name: (2S,3R)-3-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: (2S,3R)-3-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID;3-Phenyl-L-Proline;trans-3-phenyl-l-proline;(2S,3R)-3-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID 98%;(2S,3R)-3-Phenylpyrrolidine-2-carboxylic acid,98%;(2S,3R)-(+)-3-Phenylpyrrolidone-2-carboxylic acid;3-Phenyl-D-proline;(2S)-3-phenylpyrrolidine-2-carboxylic acid
• CAS NO: 118758-48-8
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 118758-48-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 234-236 °C
• Boiling Point: 326.97°C (rough estimate)
• Flash Point: 179.3 °C
• Appearance: White to off-white/Powder
• Density: 1.1258 (rough estimate)
• Vapor Pressure: 3.22E-06mmHg at 25°C
• Refractive Index: 1.5220 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.19±0.40(Predicted)
• CAS DataBase Reference: (2S,3R)-3-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-3-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID(118758-48-8)
• EPA Substance Registry System: (2S,3R)-3-PHENYLPYRROLIDINE-2-CARBOXYLIC ACID(118758-48-8)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26
• Hazardous Substances Data: 118758-48-8(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white powder

InChI:InChI=1/C11H13NO2/c13-11(14)10-9(6-7-12-10)8-4-2-1-3-5-8/h1-5,9-10,12H,6-7H2,(H,13,14)/t9-,10-/m0/s1

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 144564-13-6 4S,5S-1-t-butoxycarbonyl-5-t-butyldiphenylsiloxymethyl-4-phenylpyrrolidine-2-one 
• 108-86-1 bromobenzene 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 
• 700367-14-2 tert-butyl (2R,3R)-2-(hydroxymethyl)-3-phenylpyrrolidine-1-carboxylate 
• 212612-57-2 methyl (2S,3R)-N-(tert-butoxycarbonyl)-β-phenylprolinate 
• 123724-21-0 (2S,3R)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 158038-38-1 (2S,3R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1344157-35-2 (S)-3-((S)-2-acetamido-3-methylbutanamido)-4-(((S)-1-((2S,3R)-2-(((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)carbamoyl)-3-phenylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid 
• 281655-32-1 (2S,3R)-3-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 
• 123724-21-0 (2S,3R)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 1052146-93-6 (2S,3R)-3-Cyclohexyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 696645-31-5 (2S,3R)-3-Cyclohexyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 462123-82-6 (2S,3R)-3-Cyclohexyl-pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Intermediate used for synthesis of (2S, 3R)-3-substituted phenyl pyrrolidine-2-carboxylic acid, and preparation method and applications thereof

The invention relates to an intermediate used for synthesis of (2S, 3R)-3-substituted phenyl pyrrolidine-2-carboxylic acid, and a preparation method and applications thereof. The preparation method ismainly used for solving a technical problem that no app

Synthesis of Homochiral 3-Substituted Glutamic Acids and Prolines from Pyroglutamic Acid

Efficient syntheses of (2S,3S)-methylproline (5a) and (2S,3R)-phenylproline (5b) are described, starting from the readily available pyroglutaminol derivatives 2a and 2b via conjugate 1,4=addition of organocuprates to 1.Catalytic hydrogenation of 3 from th