1052174-82-9

Upstream product

• 1052174-67-0 C₁₆H₁₅F₂IO₃S 
• 149-30-4 2-Mercaptobenzothiazole 
• 1034144-28-9 (1,3-benzothiazol-2-ylsulfanyl)methyl phenyl sulfone 
• 108-98-5 thiophenol 
• 1535-67-7 difluoromethyl phenyl sulfide 
• 1535-65-5 difluoromethyl phenyl sulfone 

Relevant academic research and scientific papers

C-H Electrophilic (phenylsulfonyl)difluoromethylation of (hetero)arenes with a newly designed reagent

The synthesis of an original electrophilic difluoromethylating reagent was successfully achieved upon a straightforward protocol (3 steps). Like a Swiss army knife, this bench-stable reagent allowed the functionalization of various classes of compounds under mild and transition metal-free conditions. Hence, an efficient and operationally simple tool for the construction of C(sp2)-, C(sp3)- and S-CF2SO2Ph bonds was provided, expanding the chemical space of PhSO2CF2-containing molecules. Late-stage functionalization of bioactive molecules and the synthesis of PhSO2CF2- and HCF2-analogs of Lidocaine were also successfully achieved.

Electrophilic (phenylsulfonyl)difluoromethylation of thiols with a hypervalent iodine(III)-CF2SO2Ph reagent

A hypervalent iodine(III)-CF2SO2Ph compound (3) has been successfully prepared with selective nucleophilic reaction using PhSO2CF2SiMe3 reagent, and this previously unkown compound 3 was found to act as a new electrophilic (phenylsulfonyl)difluoromethylation reagent for a variety of S-nucleophiles under very mild reaction conditions.

Julia olefination as a general route to phenyl (α-fluoro)vinyl sulfones

Mild and efficient synthesis of phenyl (α-fluoro)vinyl sulfones via condensation of aldehydes and a ketone with a novel benzothiazolyl based bis-sulfone reagent is reported and this proceeds with moderate to good Z-stereoselectivity. Georg Thieme Verlag Stuttgart.