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• 946-49-6 4-(p-nitrophenyl)-3-butene-2-one 
• 75-52-5 nitromethane 
• 3156-41-0 1-nitro-4-(2-nitrovinyl)benzene 
• 67-64-1 acetone 
• 3156-41-0 1-nitro-4-[(E)-2-nitroeth-1-enyl]benzene 

Relevant academic research and scientific papers

Highly Enantioselective Michael Addition of Nitroalkanes to Enones and Its Application in Syntheses of (R)-Baclofen and (R)-Phenibut

A highly enantioselective Michael addition of nitroalkanes to α,β-unsaturated ketones was developed. In the presence of a chiral primary amine-thiourea catalyst based on dehydroabietic amine, γ-nitro ketones were obtained with excellent enantioselectiviti

Optically Active 4-Substituted 5-Nitropentan-2-ones: Valuable Chiral Building Blocks for the Stereocontrolled Construction of Spiro-Pyrazolone Scaffolds with Five Contiguous Stereogenic Centers

The application of readily available optically active 4-substituted 5-nitropentan-2-ones as chiral building blocks in the stereocontrolled construction of spiro-pyrazolone scaffolds was investigated. In the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (

Asymmetric Conjugate Addition of Nitroalkanes to Enones Using a Sulfonamide-Thiourea Organocatalyst

The asymmetric conjugate addition of nitroalkanes to α,β-unsaturated ketones in the presence of a catalytic amount of a novel sulfonamide-thiourea organocatalyst resulted in the corresponding γ-nitro carbonyl products in high yields with excellent enantio

Helical-Peptide-Catalyzed Enantioselective Michael Addition Reactions and Their Mechanistic Insights

Helical peptide foldamer catalyzed Michael addition reactions of nitroalkane or dialkyl malonate to α,β-unsaturated ketones are reported along with the mechanistic considerations of the enantio-induction. A wide variety of α,β-unsaturated ketones, including β-aryl, β-alkyl enones, and cyclic enones, were found to be catalyzed by the helical peptide to give Michael adducts with high enantioselectivities (up to 99%). On the basis of X-ray crystallographic analysis and depsipeptide study, the amide protons, N(2)-H and N(3)-H, at the N terminus in the α-helical peptide catalyst were crucial for activating Michael donors, while the N-terminal primary amine activated Michael acceptors through the formation of iminium ion intermediates.

C3-symmetric proline-functionalized organocatalysts: Enantioselective michael addition reactions

C3-Symmetric, tripodal catalyst 4 based on 1,3,5- triethylbenzene, which incorporates the features of a molecular receptor, is shown to catalyze Michael addition reactions ofcarbonyl compounds to β-nitrostyrenes in a high stereoselectivity (up to 99:1a dr and up to 98%ee). Copyright

Primary amine-thioureas based on tert-butyl esters of natural amino acids as organocatalysts for the Michael reaction

A new class of primary amine-thioureas based on tert-butyl esters of (S)-α-amino acids and (1S,2S)-diphenylethylenediamine was synthesized and their activity as catalysts in Michael additions was evaluated. Derivatives based on di-tert-butyl aspartate and

A novel bifunctional sulfonamide primary amine-catalyzed enantioselective conjugate addition of ketones to nitroolefins

The enantioselective conjugate addition of a variety of ketones to nitroolefins has been developed. The process is efficiently catalyzed by a novel bifunctional sulfonamide primary amine in good yields and with good levels of enantioselectivity.

Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to α,β-unsaturated ketones

Cinchona alkaloid derived primary amine thioureas organocatalyzed Michael addition of nitroalkanes to enones in good yield and up to 98% ee and offered a new way to construct quaternary stereocenters from enones and nitroalkanes. The Royal Society of Chem