1052184-89-0Relevant academic research and scientific papers
Facile synthesis and stereo-resolution of chiral 1,2,3-triazoles
Shi, Ye,Ye, Xiaohan,Gu, Qiang,Shi, Xiaodong,Song, Zhiguang
, p. 5407 - 5411 (2015/05/20)
We describe herein the first facile synthesis of chiral triazoles through side chain functionalization. Readily available C-vinyl triazoles were used as starting materials, followed by sequential epoxidation, rearrangement and reduction to give the corresponding hydroxyl-triazoles. The CalB lipase catalyzed kinetic resolution gave enantiomerically pure (>99% ee) chiral triazoles in excellent yield. These new chiral TAs were also successfully applied as ligands in asymmetric addition of diethylzinc to aldehydes.
Conformational control in the regioselective synthesis of N-2-substituted-1,2,3-triazoles
Chen, Yunfeng,Liu, Yuxiu,Petersen, Jeffrey L.,Shi, Xiaodong
supporting information; experimental part, p. 3254 - 3256 (2009/02/04)
An effective strategy for the synthesis of N-2-substituted-1,2,3-triazoles with excellent yields and regioselectivity has been developed. The Royal Society of Chemistry.
