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(4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE is a chemical compound characterized by a fluorine-substituted phenyl ring with a hydrazine functional group attached. Its unique structure, featuring a trifluoromethyl group and a fluorine atom, makes it a valuable intermediate in the synthesis of pharmaceuticals and agrochemicals. The presence of these functional groups enhances the bioavailability and metabolic stability of drug candidates, while also making it suitable for the development of imaging agents and radiotracers for medical imaging modalities. However, due to its potential toxicity and environmental risks, careful handling and disposal are essential.

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  • 105224-02-0 Structure
  • Basic information

    1. Product Name: (4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE
    2. Synonyms: (4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE
    3. CAS NO:105224-02-0
    4. Molecular Formula: C7H6F4N2
    5. Molecular Weight: 194.13
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 105224-02-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: (4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE(105224-02-0)
    11. EPA Substance Registry System: (4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE(105224-02-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 105224-02-0(Hazardous Substances Data)

105224-02-0 Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its trifluoromethyl and fluorine-containing structure contributes to the improved bioavailability and metabolic stability of the final drug candidates, enhancing their therapeutic efficacy.
Used in Medical Imaging:
(4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE is utilized in the development of imaging agents and radiotracers for positron emission tomography (PET) and other medical imaging modalities. The presence of the fluorine atom allows for effective labeling and tracking of biological processes, aiding in the diagnosis and monitoring of diseases.
Used in Research and Development:
In the field of research and development, (4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE serves as a valuable compound for exploring new chemical reactions and synthetic pathways. Its unique structure allows chemists to investigate its reactivity and potential applications in various chemical transformations, leading to the discovery of novel compounds with potential uses in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 105224-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,2,2 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 105224-02:
(8*1)+(7*0)+(6*5)+(5*2)+(4*2)+(3*4)+(2*0)+(1*2)=70
70 % 10 = 0
So 105224-02-0 is a valid CAS Registry Number.

105224-02-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [4-Fluoro-3-(trifluoromethyl)phenyl]hydrazine

1.2 Other means of identification

Product number -
Other names 4-fluoro-3-trifluoromethyl-phenyl-hydrazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105224-02-0 SDS

105224-02-0Downstream Products

105224-02-0Relevant articles and documents

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

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Page/Page column 124; 135; 136, (2014/01/08)

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Thrombopoietin Receptor Agonists

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Page/Page column 31, (2010/11/30)

A compound of the formula (I) useful as promoters of thrombopoiesis and megakaryocytopoiesis, wherein A, B, D, E, W, X, Y, Z, R1 and R2 are defined as above.

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