105250-98-4

Upstream product

• 59490-96-9 4-chloro-2-(p-tolyl)quinazoline 
• 18818-41-2 2-(4-methylphenyl)-4(3H)-quinazolinone 
• 13324-79-3 2,3-dihydro-2-(4-methylphenyl)quinazolin-4(1H)-one 
• 28144-70-9 anthranilic acid amide 
• 104-87-0 4-methyl-benzaldehyde 
• 2454-39-9 2-aminobenzothioamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 100698-06-4 2-mercapto-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione pyridinium salt 
• 59525-07-4 4-methyl-N-(2-thiocarbamoyl-phenyl)-benzamide 

Downstream Products

• 450379-31-4 C₁₅H₁₄N₄ 
• 1448068-52-7 C₁₆H₁₃N₅ 
• 105251-03-4 3-(bromomethyl)-2,3-dihydro-5-(4-methylphenyl)thiazolo<3,2-c>quinazolin-4-ium bromide 
• 105251-24-9 3-(bromomethyl)-5-(4-methylphenyl)thiazolo<3,2-c>quinazolin-4-ium bromide 
• 105251-07-8 4-<(2,3-dibromopropyl)thio>-2-(4-methylphenyl)quinazoline 
• 105251-20-5 2-(4-methylphenyl)-4-(propargylthio)quinazoline 
• 105251-00-1 4-(allylthio)-2-(4-methylphenyl)quinazoline 

Relevant academic research and scientific papers

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

Synthesis and anticonvulsant activity evaluation of 5-Phenyl-[1,2,4] triazolo[4,3-c]quinazolin-3-amines

In the present study we describe the syntheses and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amine derivatives. Their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock seizure test (MES) and the rotarod test, respectively. The majority of the compounds prepared were effective in the MES screens at a dose level of 100 mg/kg. Of these compounds, the most promising was compound 8h, which showed an ED50 value of 27.4 mg/kg and a protective index (PI) value of 5.8. These values were superior to those provided by valproate (ED50 and PI values of 272 and 1.6, respectively) in the MES test in mice. As well as its anti-MES efficacy, the potencies of compound 8h against seizures induced by pentylenetetrazole and thiosemicarbazide were also established, with the results suggesting that the GABAergic system-mediated mechanisms might be involved in its anticonvulsant activity. Copyright

Synthesis of substituted 2-benzoylaminothiobenzamides and their ring closure to substituted 2-phenylquinazoline-4-thiones

Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoyl-aminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding quinazoline-4-thiones. These compounds were characterised by means of their 1H- and 13C-NMR spectra. The preferred tautomeric form of selected compounds has been discussed on the basis of their 13C-NMR, IR and Raman spectra. It has been found that in the given medium 1-methyl-quinazoline-4-thiones undergo a replacement of the sulphur substituent by oxygen giving 1-methyl-quinazoline-4-ones. In strong acid media, 2-benzoylaminothiobenzamide is cyclised through its sulphur atom to give 2-phenylbenzo[d-1,3]thiazin-4-one.