105250-98-4

Basic information

• Product Name: 4(1H)-Quinazolinethione, 2-(4-methylphenyl)-
• CAS NO: 105250-98-4
• Molecular Formula: C15H12N2S
• Molecular Weight: 252.34
• Mol File: 105250-98-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinazolinethione, 2-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinethione, 2-(4-methylphenyl)-(105250-98-4)
• EPA Substance Registry System: 4(1H)-Quinazolinethione, 2-(4-methylphenyl)-(105250-98-4)

Safety Data

• Hazardous Substances Data: 105250-98-4(Hazardous Substances Data)

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 59490-96-9 4-chloro-2-(p-tolyl)quinazoline 
• 18818-41-2 2-(4-methylphenyl)-4(3H)-quinazolinone 
• 13324-79-3 2,3-dihydro-2-(4-methylphenyl)quinazolin-4(1H)-one 
• 28144-70-9 anthranilic acid amide 
• 104-87-0 4-methyl-benzaldehyde 
• 2454-39-9 2-aminobenzothioamide 
• 100698-06-4 2-mercapto-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione pyridinium salt 
• 59525-07-4 4-methyl-N-(2-thiocarbamoyl-phenyl)-benzamide 

Downstream Products

• 105251-00-1 4-(allylthio)-2-(4-methylphenyl)quinazoline 
• 1448068-52-7 C₁₆H₁₃N₅ 
• 450379-31-4 C₁₅H₁₄N₄ 
• 105251-03-4 3-(bromomethyl)-2,3-dihydro-5-(4-methylphenyl)thiazolo<3,2-c>quinazolin-4-ium bromide 
• 105251-24-9 3-(bromomethyl)-5-(4-methylphenyl)thiazolo<3,2-c>quinazolin-4-ium bromide 
• 105251-07-8 4-<(2,3-dibromopropyl)thio>-2-(4-methylphenyl)quinazoline 
• 105251-20-5 2-(4-methylphenyl)-4-(propargylthio)quinazoline 

Relevant articles and documents

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

Synthesis of substituted 2-benzoylaminothiobenzamides and their ring closure to substituted 2-phenylquinazoline-4-thiones

Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoyl-aminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding quinazoline-4-thiones. These compounds were characterised by means of their 1H- and 13C-NMR spectra. The preferred tautomeric form of selected compounds has been discussed on the basis of their 13C-NMR, IR and Raman spectra. It has been found that in the given medium 1-methyl-quinazoline-4-thiones undergo a replacement of the sulphur substituent by oxygen giving 1-methyl-quinazoline-4-ones. In strong acid media, 2-benzoylaminothiobenzamide is cyclised through its sulphur atom to give 2-phenylbenzo[d-1,3]thiazin-4-one.