18818-41-2

Basic information

• Product Name: 2-(4-Methylphenyl)-quinazolin-4(3H)-one
• Synonyms: 2-(4-Methylphenyl)-quinazolin-4(3H)-one;2-(4-methylphenyl)-4(3H)-quinazolinone;2-P-TOLYLQUINAZOLIN-4(3H)-ONE
• CAS NO: 18818-41-2
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.26858
• Mol File: 18818-41-2.mol
• Article Data: 190

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Methylphenyl)-quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylphenyl)-quinazolin-4(3H)-one(18818-41-2)
• EPA Substance Registry System: 2-(4-Methylphenyl)-quinazolin-4(3H)-one(18818-41-2)

Safety Data

• Hazardous Substances Data: 18818-41-2(Hazardous Substances Data)

Usage

Core structure

Quinazolinone core.

Derivative

It is a derivative of quinazoline.

Biological activities

Anti-tumor, anti-inflammatory, and anti-microbial properties.

Potential use

In cancer therapy.

Promising results

Inhibiting the growth of certain cancer cell lines.

Anti-inflammatory effects

Suppressing the production of inflammatory mediators.

Versatile compound

Potential applications in medicine and pharmacology.

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 874-60-2 4-methyl-benzoyl chloride 
• 118-92-3 anthranilic acid 
• 104-85-8 para-methylbenzonitrile 
• 104-84-7 para-methylbenzylamine 
• 201230-82-2 carbon monoxide 
• 106-38-7 para-bromotoluene 
• 1885-29-6 anthranilic acid nitrile 
• 40928-15-2 2-amino-N-methoxy-benzamide 
• 2789-88-0 1,2-bis(4-methylphenyl)acetylene 
• 2042-37-7 o-cyanobromobenzene 
• 1486-28-8 diphenyl(methyl)phosphine 
• 287976-89-0 N-(4-methylbenzoyl)-2-azidobenzamide 

Downstream Products

• 1448068-52-7 C₁₆H₁₃N₅ 
• 105250-98-4 2-p-tolylquinazoline-4(3H)-thione 
• 450379-31-4 C₁₅H₁₄N₄ 
• 16112-44-0 2-(4-methylphenyl)-4-phenyl-quinazoline 
• 1446786-00-0 2-(4-methylphenyl)-4-(4-methylphenyl)quinazoline 
• 121513-89-1 4-(4-methoxyphenyl)-2-(p-tolyl)quinazoline 
• 1520087-38-0 4-(4-chlorophenyl)-2-(p-tolyl)quinazoline 
• 1233224-85-5 C₂₃H₁₈N₄O 
• 1233224-89-9 3-[1-hydroxy-1-(4-nitrophenyl)methyl]-5-(4-methylphenyl)[1,2,4]triazolo[4,3-c]quinazoline 
• 65772-26-1 3-morpholin-4-ylmethyl-2-p-tolyl-3H-quinazolin-4-one 

Relevant articles and documents

N^N^O hydrazone capped pincer type palladium complex catalysed construction of quinazolinones from alcohols

New Pincer type Pd(II) complex [Pd(NNO)(PPh3)] (1) prompted synthesis of quinazolinones via dehydrogenative coupling of readily accessible alcohols, and o-aminobenzamide is described. A diverse range of quinazolinones has been synthesized efficiently with good to excellent yields employing low catalyst loading (0.5 mol%) under the aerobic condition without any additives/oxidants. A plausible mechanism for the construction of quinazolinones has been proposed via cyclic aminal intermediate. Large-scale synthesis attests to the productiveness of the current strategy.

Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst

Herein, we report a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and anin situgenerated non-native secondary amine. The catalyst consists of ano-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones fromo-nitrobenzamide and alcohols

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily availableo-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including