105252-99-1

Basic information

• Product Name: 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI)
• Synonyms: 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI);4-aMino-6-fluoro-2(1H)pyridinone;4-Amino-6-fluoropyridin-2(1H)-one;4-amino-6-fluoro-1H-pyridin-2-one
• CAS NO: 105252-99-1
• Molecular Formula: C5H5FN2O
• Molecular Weight: 128.1044032
• Product Categories: PYRIDINE
• Mol File: 105252-99-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI)(105252-99-1)
• EPA Substance Registry System: 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI)(105252-99-1)

Safety Data

• Hazardous Substances Data: 105252-99-1(Hazardous Substances Data)

Usage

General Description

2(1H)-Pyridinone, 4-amino-6-fluoro-(9CI) is a chemical compound with the molecular formula C5H5FN2O. It is a derivative of pyridine and contains an amino group and a fluorine atom at the 4 and 6 positions, respectively. 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI) is an important building block in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs and crop protection products due to its ability to interact with biological targets. Additionally, the presence of the fluorine atom makes it a useful tool for studying molecular interactions and as a component in pharmaceuticals for positron emission tomography (PET) imaging.

Upstream product

• 2840-00-8 4-amino-3,5-dichloro-2,6-difluoropyridine 
• 63489-58-7 4-amino-2,6-difluoropyridine 

Relevant articles and documents

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors

Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fused, bicyclic screening hit for potency, selectivity, and physicochemical properties in order to further expand the chemical diversity of allosteric SHP2 inhibitors. In this manuscript, we describe the further expansion of our approach, morphing the fused, bicyclic system into a novel monocyclic pyrimidinone scaffold through our understanding of SAR and use of structure-based design. These studies led to the identification of SHP394 (1), an orally efficacious inhibitor of SHP2, with high lipophilic efficiency, improved potency, and enhanced pharmacokinetic properties. We also report other pyrimidinone analogues with favorable pharmacokinetic and potency profiles. Overall, this work improves upon our previously described allosteric inhibitors and exemplifies and extends the range of permissible chemical templates that inhibit SHP2 via the allosteric mechanism.

Synthesis and antitumor activity of fluorine-substituted 4-amino-2(1H)-pyridinones and their nucleosides. 3-Deazacytosines

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