105252-99-1

Usage

Uses

Used in Pharmaceutical Industry:
2(1H)-Pyridinone,4-amino-6-fluoro-(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to interact with biological targets, contributing to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI) is utilized as a precursor in the production of crop protection products, enhancing their effectiveness in managing pests and diseases while minimizing environmental impact.
Used in Molecular Interaction Studies:
2(1H)-Pyridinone,4-amino-6-fluoro-(9CI) is employed as a research tool in molecular interaction studies, providing insights into the binding mechanisms and interactions of biologically active molecules.
Used in Positron Emission Tomography (PET) Imaging:
The presence of the fluorine atom in 2(1H)-Pyridinone,4-amino-6-fluoro-(9CI) makes it a valuable component in the development of pharmaceuticals for PET imaging, aiding in the visualization and diagnosis of various diseases at the molecular level.

Upstream product

• 2840-00-8 4-amino-3,5-dichloro-2,6-difluoropyridine 
• 63489-58-7 4-amino-2,6-difluoropyridine 

Relevant academic research and scientific papers

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors

Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fused, bicyclic screening hit for potency, selectivity, and physicochemical properties in order to further expand the chemical diversity of allosteric SHP2 inhibitors. In this manuscript, we describe the further expansion of our approach, morphing the fused, bicyclic system into a novel monocyclic pyrimidinone scaffold through our understanding of SAR and use of structure-based design. These studies led to the identification of SHP394 (1), an orally efficacious inhibitor of SHP2, with high lipophilic efficiency, improved potency, and enhanced pharmacokinetic properties. We also report other pyrimidinone analogues with favorable pharmacokinetic and potency profiles. Overall, this work improves upon our previously described allosteric inhibitors and exemplifies and extends the range of permissible chemical templates that inhibit SHP2 via the allosteric mechanism.

Selective sodium channel regulator, preparation and application thereof

The invention provides a compound as a selective sodium channel regulator, a synthesis method and a use method thereof, and particularly provides a compound as shown in a formula (I), a preparation method of the compound and application of the compound as the selective sodium channel regulator. The compounds exhibit excellent activity as sodium channel modulators.