105259-82-3

Basic information

• Product Name: tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate
• Synonyms: tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate
• CAS NO: 105259-82-3
• Molecular Weight: 677.882
• Mol File: 105259-82-3.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate(105259-82-3)
• EPA Substance Registry System: tert-butyl N--L-alanyl>-N-(2-indanyl)glycinate(105259-82-3)

Safety Data

• Hazardous Substances Data: 105259-82-3(Hazardous Substances Data)

Upstream product

• 2942-58-7 diethyl cyanophosphonate 
• 83402-63-5 tert-butyl N-(2,3-dihydro-1H-inden-2-yl)glycinate 
• 100277-54-1 ethyl (2R)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-methanesulfonyloxyhexanoate 
• 100277-52-9 ethyl (2R)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate 
• 105259-97-0 tert-butyl-N-<(1S)-5-(1-benzyloxycarbonyl-4-piperidyl)-1-ethoxycarbonylpentyl>-L-alaninate 
• 99198-61-5 ethyl 6-(1-benzyloxycarbonyl-4-piperidyl)-2-oxohexanoate 
• 108428-37-1 N-(L-alanyl)-N-(2-indanyl)glycine tert-butyl ester oxalate 

Relevant articles and documents

Synthesis and angiotensin converting enzyme-inhibitory activity of N- [(1S)-1-carboxy-5-(4-piperidyl)pentyl]-L-alanine derivatives

As part of a search for potent and long-lasting angiotensin converting enzyme (ACE) inhibitors, various types of N-[(1S)-1-carboxy-5-(4- piperidyl)pentyl]-L-alanine derivatives (7a, 8-11) were prepared. The key synthetic intermediate, N-[(1S)-5-(1-benzyloxycarbonyl-4-piperidyl)-1- ethoxycarbonylpentyl]-L-alanine (17a), was synthesized by asymmetric reduction of the α-oxoester (13) with Lactobacillus paracasei subsp. paracasei followed by a substitution reaction with tert-butyl L-alanine (15) and subsequent treatment with hydrogen chloride. Compounds 7a and 8-11 showed potent and long-lasting ACE-inhibitory activity in rats.

Piperidine derivatives

Novel Compounds of the formula: STR1 [wherein A is an α-amino acid residue; B is a group represented by the formula: STR2 (wherein R4 is hydrogen, lower alkyl, aralkyl or amino-lower alkyl), whereby the linkage between the symbols A and B desig