1052670-06-0

Basic information

• Product Name: (2S,3R,4S,5S)-3-chloro-1,5-dimethyl-2,4-diphenylpyrrolidine
• Synonyms: (2S,3R,4S,5S)-3-chloro-1,5-dimethyl-2,4-diphenylpyrrolidine
• CAS NO: 1052670-06-0
• Molecular Weight: 285.817
• Mol File: 1052670-06-0.mol

Chemical Properties

• CAS DataBase Reference: (2S,3R,4S,5S)-3-chloro-1,5-dimethyl-2,4-diphenylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R,4S,5S)-3-chloro-1,5-dimethyl-2,4-diphenylpyrrolidine(1052670-06-0)
• EPA Substance Registry System: (2S,3R,4S,5S)-3-chloro-1,5-dimethyl-2,4-diphenylpyrrolidine(1052670-06-0)

Safety Data

• Hazardous Substances Data: 1052670-06-0(Hazardous Substances Data)

Upstream product

• 515824-05-2 (1'R,2S,3S,4S)-(1,4-dimethyl-3-phenylazetidin-2-yl)phenylmethanol 

Relevant articles and documents

Ring expansion of 2-(α-hydroxyalkyl)azetidines: A synthetic route to functionalized pyrrolidines

A series of 2-(α-hydroxyalkyl)azetidines synthesized from enantiomerically pure β-amino alcohols and presenting various patterns both on the four-membered ring and on the adjacent hydroxy group were treated with either thionyl chloride or methanesulfonyl chloride in the presence of triethylamine. The thus-prepared 2-(α-chloro- or α- methanesulfonyloxyalkyl) azetidines were shown to rearrange stereospecifically into 3-(chloro- or methanesulfonyloxy)pyrrolidines. When this rearrangement is conducted in the presence of an added nucleophile (NaN3, KCN, KOH, or NaOAc), the produced pyrrolidine incorporates the added nucleophile at C-3 stereospecifically. The relative configuration of the substituents in the formed pyrrolidines is consistent with a mechanism involving the formation of an intermediate bicyclic aziridinium ion, which is opened regioselectively at the bridgehead carbon atom. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.